33500-20-8

Basic information

• Product Name: 2-[Bis(methylthio)methyl]furan
• Synonyms: 2-[Bis(methylthio)methyl]furan;2-Bis(methylthio)methylfuran
• CAS NO: 33500-20-8
• Molecular Formula: C₇H₁₀OS₂
• Molecular Weight: 0
• Mol File: 33500-20-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[Bis(methylthio)methyl]furan(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[Bis(methylthio)methyl]furan(33500-20-8)
• EPA Substance Registry System: 2-[Bis(methylthio)methyl]furan(33500-20-8)

Safety Data

• Hazardous Substances Data: 33500-20-8(Hazardous Substances Data)

Upstream product

• 98-01-1 furfural 
• 997-49-9 trithioboric acid trimethyl ester 
• 74-93-1 methylthiol 

Downstream Products

• 88159-80-2 (4R)-1-(o-nitrobenzyloxycarbonyltriphenylphosphoranylidene)methyl-4-(2,2'-furanyl-2,2-dimethylthio)ethyl-azetidin-2-one 
• 88139-54-2 (4R)-1-(o-nitrobenzyloxycarbonyltriphenylphosphoranylidene)methyl-4-(2-furanylcarbonyl)methyl-azetidin-2-one 
• 88139-87-1 (4R)-1-o-nitrobenzyloxycarbonylhydroxymethyl-4-(2,2'-furanyl-2,2-dimethylthio)ethyl-azetidin-2-one 
• 88139-67-7 o-nitrobenzyl (5R)-2-(2-furanyl)-1-carbapen-2-em-3-carboxylate 

Relevant articles and documents

Surprising reaction of 5-(phenylthio)- and 5-(methylthio)pent-2-en-4- inal with HCl

Contrary to expectations (Scheme 1), 5-(phenylthio)-(1a) as well as 5- (methylthio)pent-2-en-4-inal (1b) react with a slight excess of HCl to give 2-[bis(phenylthio)mcthyl]furan (17a, 77% yield) and 2- [bis(methylthio)methyl]furan (17b, 61% yield), respectively. Structures 17a and 17b are supported by the results of an X-ray crystal-structure analysis, by spectroscopic data in comparison to those of model compounds, and by synthesis of 17a. This surprising reaction is tentatively explained by a mechanism (Scheme 4), including a special pyran → furan ring-contraction sequence, which is in agreement with a labelling experiment.