Guanosine Tetraphosphate, also known as (p)ppGpp, is a bacterial signaling molecule that plays a vital role in the stringent response, a regulatory mechanism in bacteria that allows them to adapt to environmental stress, such as nutrient deprivation and antibiotic treatment. It is a nucleotide derivative of guanosine and modulates various cellular processes, including transcription, translation, and replication, to maintain cellular homeostasis. Its presence in bacteria is associated with virulence, antibiotic tolerance, and persistence, making (p)ppGpp a potential target for the development of new antibacterial agents.
33503-72-9
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Basic information
- Product Name: Guanosine Tetraphosphate
- Synonyms: Guanosine Tetraphosphate
- CAS NO:33503-72-9
- Molecular Formula: C10H17N5O17P4
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: N/A
- Mol File: 33503-72-9.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 1134.2°Cat760mmHg
- Flash Point: 639.7°C
- Appearance: /
- Density: 2.85g/cm3
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: Guanosine Tetraphosphate(CAS DataBase Reference)
- NIST Chemistry Reference: Guanosine Tetraphosphate(33503-72-9)
- EPA Substance Registry System: Guanosine Tetraphosphate(33503-72-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 33503-72-9(Hazardous Substances Data)
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33503-72-9 Usage
Uses
Used in Pharmaceutical Industry:Guanosine Tetraphosphate is used as a target for the development of new antibacterial agents due to its role in bacterial virulence, antibiotic tolerance, and persistence.
Used in Research and Development:
Guanosine Tetraphosphate is used as a research tool to study the stringent response and its impact on bacterial adaptation to environmental stress, gene expression, and metabolism. Understanding the role of (p)ppGpp in these processes can provide insights into the development of novel antibacterial strategies and therapies.
Used in Diagnostics:
Guanosine Tetraphosphate can be used as a biomarker to monitor bacterial stress responses and assess the effectiveness of antibiotic treatments. Detecting changes in (p)ppGpp levels can help in the early identification of antibiotic resistance and the development of personalized treatment plans.
Used in Synthetic Biology:
Guanosine Tetraphosphate can be employed as a regulatory molecule in synthetic biology applications, where it can be engineered to control gene expression and metabolic pathways in response to specific environmental cues or stress conditions. This can enable the development of novel biosensors, bioproduction systems, and other biotechnological applications.
Check Digit Verification of cas no
The CAS Registry Mumber 33503-72-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,3,5,0 and 3 respectively; the second part has 2 digits, 7 and 2 respectively.Calculate Digit Verification of CAS Registry Number 33503-72:
(7*3)+(6*3)+(5*5)+(4*0)+(3*3)+(2*7)+(1*2)=89
89 % 10 = 9
So 33503-72-9 is a valid CAS Registry Number.
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Guanosine Tetraphosphate
