335065-57-1Relevant academic research and scientific papers
The synthesis and biological activities of 6-aryl-3-(D-glucoheptonic- hexitol-1-yl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines
Ye, Xiaoxia,Chen, Zhenfei,Zhang, Anjiang,Zhang, Lixue
, p. 244 - 246 (2008/09/21)
A series of novel 6-aryl-3-(D-glucoheptonic-hexitol-1-yl)-7H-1,2,4- triazolo[3,4-b][1,3,4] thiadiazines (2a-2j) have been synthesised in high yield by means of the reaction of 4-amino-5-mercapto-3-(D-glucoheptonic-hexitol-1-yl)- 1,2,4-triazole (1) with substituted ω-brom- oacetophenones. The structures of the compounds were determined by elemental analysis, IR, 1H NMR, 13C NMR and MS. Most possessed high plant growth-regulating activities.
Novel synthesis of seco type of acyclo C-nucleosides of 1,2,4-triazole and 1,2,4-triazolo[3,4-b][1,3,4]thiadiazine
El Ashry,Awad
, p. 103 - 116 (2007/10/03)
The seco C-nucleosides 3-(1,2,3,4,5-penta-O-acetyl-D-gluco- and Dgalacto-pentitol-1-yl)-1 H-1,2,4-triazoles (8 and 9) were obtained in a one pot by deamination and dethiolation of 4-amino-3-(.D-gluco- and D-galactopentitol-1-yl)-5-mercapto-1,2,4-triazoles (1 and 2), respectively, using sodium nitrite in orthophosphoric acid and subsequent acetylation. Condensation of 1, 2, and 4-amino-3-(D-glycero-D-gulo-hexitol-1-yl)-5-mercapto- 1,2,4-triazole (12) with phenacylbromide (11) afforded the corresponding 3-(D-gluco-, D-galactopentitol-1-yl) and 3-(D-glycero-D-gulo-hexitol-1-yl)-6-phenyl-7 H- 1,2,4triazolo[3,4-b][1,3,4] thiadiazines (15, 16, and 17). Acetylation of 15-17 gave the penta- and hexa-O-acetyl derivatives 18-20, respectively. The structures were confirmed by using 1H, 13C, and 2D NMR spectra, DQFCOSY, HMQC, and HMBC experiments. The favored conformational structures were deduced from the vicinal coupling constants of the protons.
