335081-04-4Relevant articles and documents
PROBE FOR MULTIPLE RESONANCE
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Paragraph 0092; 0093; 0096, (2016/12/16)
PROBLEM TO BE SOLVED: To provide a precursor amino acid of a neurotransmitter capable of showing a physiologic activity or a pharmacological activity as a precursor of neurotransmitter and being detected at high selectivity in organism and to provide a probe for multiple resonance showing the physiologic activity or the pharmacological activity as the precursor of neurotransmitter and being tracked a process of metabolic reactions in organism and further being detected at high selectivity in organism. SOLUTION: There is provided a precursor amino acid of neurotransmitter represented by the formula (I), where R1 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms which may have a substituent, an aryl group having 6 to 12 carbon atoms which may have a substituent, a heterocyclic group having 3 to 10 carbon atoms which may have a substituent or a carboxylic group, or a probe for multiple resonance containing the precursor amino acid of neurotransmitter as an active ingredient. COPYRIGHT: (C)2015,JPOandINPIT
1H NMR probe for in situ monitoring of dopamine metabolism and its application to inhibitor screening
Ueki, Ryosuke,Yamaguchi, Koya,Nonaka, Hiroshi,Sando, Shinsuke
, p. 12398 - 12401 (2012/08/29)
Dopamine (DA) is a monoamine neurotransmitter that plays important roles in the brain, and whose levels in the brain are associated with several neurological and psychiatric disorders. Therefore, DA metabolism inhibitors have been used as therapeutic agents. Here, we report a 1H NMR probe for the in situ analysis of DA metabolism, and its application to DA inhibitor screening. We designed doubly 13C-labeled DA (13C 2-DA) as the probe. The combination of the 13C 2-DA and 1H-{13C-13C′} NMR technique allowed the selective and thus in situ monitoring of DA metabolism. Using 13C2-DA, we successfully measured the efficacies of different inhibitors in a tissue sample, allowing us to improve the in situ inhibitory efficacy of the known DA metabolism inhibitor, clorgyline.
Synthesis of Dopamines Labelled with 13C in the α- or β-Side Chain Position and Their Application to Structural Studies on Melanins by Solid-State NMR Spectroscopy
Crescenzi, Orlando,Kroesche, Christoph,Hoffbauer, Wilfried,Jansen, Martin,Napolitano, Alessandra,et al.
, p. 563 - 568 (2007/10/02)
Solid-state NMR spectroscopy was applied to the analysis of melanins prepared by peroxidase-H2O2 oxidation of dopamines specifically 13C labelled in the α- or β-side chain positions.A surprisingly diverse pattern of signals indicated the presence of uncyclized dopamine and noradrenaline-derived units, in addition to indole and carbonyl carbon atoms.These structural features, coupled with the results obtained from elemental analysis of dopamine melanin samples prepared under different conditions, point to a pigment formation process more complex than previously believed. - Key Words: CP-MAS NMR Spectroscopy / Melanin / Oxidative phenolic coupling / Quinone methides / Labelled compounds, 13C / Dopamines / Enzymes
The Biosynthesis of the Cularine Alkaloids
Mueller, Martin J.,Zenk, Meinhart H.
, p. 557 - 564 (2007/10/02)
In order to study the cularine biosynthesis, L-tyrosine (L-18), tyramine (20), L-DOPA (L-19) and dopamine (21) were synthesized and fed to Corydalis claviculata and Sarcocapnos crassifolia plants, which are rich source
