3351-93-7

Basic information

• Product Name: 2-BROMO-N-(2-METHOXYPHENYL)PROPANAMIDE
• Synonyms: 2-BROMO-N-(2-METHOXYPHENYL)PROPANAMIDE
• CAS NO: 3351-93-7
• Molecular Formula: C₁₀H₁₂BrNO₂
• Molecular Weight: 258.11
• Mol File: 3351-93-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-BROMO-N-(2-METHOXYPHENYL)PROPANAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-N-(2-METHOXYPHENYL)PROPANAMIDE(3351-93-7)
• EPA Substance Registry System: 2-BROMO-N-(2-METHOXYPHENYL)PROPANAMIDE(3351-93-7)

Safety Data

• Hazardous Substances Data: 3351-93-7(Hazardous Substances Data)

Upstream product

• 90-04-0 2-methoxy-phenylamine 
• 563-76-8 α-bromopropionyl bromide 
• 7148-74-5 2-Bromopropionyl chloride 

Downstream Products

• 1604039-73-7 ethyl (2-methoxyphenyl)(2-methyl-4-(triisopropylsilyl)but-3-yn-1-yl)carbamate 
• 1604039-17-9 N-(2-bromopropyl)-2-methoxyaniline 
• 1604039-12-4 ethyl (2-bromopropyl)(2-methoxyphenyl)carbamate 
• 47502-10-3 N-<2-Methoxy-phenyl>-2--propionsaeureamid 
• 801978-87-0 N-<2-Methoxy-phenyl>-2-<2-(2-methoxy-phenoxy)-aethylamino>-propionsaeureamid 

Relevant articles and documents

Comparative conventional and microwave assisted synthesis of heterocyclic oxadiazole analogues having enzymatic inhibition potential

A comparative microwave assisted and conventional synthetic strategies were applied to synthesize heterocyclic 1,3,4-oxadiazole analogues as active anti-enzymatic agents. Green synthesis of compound 1 was achieved by stirring 4-methoxybenzenesulfonyl chloride (a) and ethyl piperidine-4-carboxylate (b). Compound 1 was converted into respective hydrazide (2) by hydrazine and then into 1,3,4-oxadiazole (3) by CS2 on reflux. The electrophiles, N-alkyl/aralkyl/aryl-2-bromopropanamides (6a–p) were synthesized and converted to N-alkyl/aralkyl/aryl-2-propanamide derivatives (7a–p) by reaction with 3 under green chemistry. Microwave assisted method was found to be effective relative to conventional method. 13C-NMR, 1H-NMR and IR techniques were availed to corroborate structures of synthesized compounds and then subjected to screening against lipoxygenase (LOX), α-glucosidase, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. A number of compounds presented better potential against these enzymes. The most active compounds against LOX and α-glucosidase enzymes were subjected to molecular docking study to explore their interactions with the active sites of the enzymes.

Mild and phosphine-free iron-catalyzed cross-coupling of nonactivated secondary alkyl halides with alkynyl grignard reagents

A simple protocol for iron-catalyzed cross-coupling of nonactivated secondary alkyl bromides and iodides with alkynyl Grignard reagents at room temperature has been developed. A wide range of secondary alkyl halides and terminal alkynes are tolerated to a