335160-75-3

Upstream product

• 335160-63-9 (1S)-tert-butyl-1-{[(chloroacetyl)(2,4-dimethoxybenzyl)amino]-methyl}but-3-enylcarbamate 
• 335160-61-7 (1S)-tert-butyl-1-{[(2,4-dimethoxybenzyl)amino]methyl}but-3-enylcarbamate 
• 208521-14-6 (S)-2-[N²-[(tert-butyloxy)carbonyl]amino]-N-methoxy-N-methyl-4-penteneamide 
• 90600-20-7 (2S)-2-[(tert-butoxycarbonyl)amino]pent-4-enoic acid 
• 95107-99-6 tert-butyl (S)-(1-oxopent-4-en-2-yl)carbamate 
• 20781-21-9 2,4-dimethoxybenzylamine hydrochloride 

Relevant academic research and scientific papers

3,8-Diazabicyclo[3.2.1]octan-2-one peptide mimetics: synthesis of a conformationally restricted inhibitor of farnesyltransferase.

A new synthesis of the 3,8-diazabicyclo[3.2.1]octan-2-one framework is described. Transannular enolate alkylation of piperazinone derivatives provides a flexible route to highly constrained bicyclic peptidomimetic synthons with substitution at the Calpha