335160-94-6

Basic information

• Product Name: [1-(5-Hydroxypentyl)-1H-indol-3-yl](2-iodophenyl)-Methanone
• Synonyms: [1-(5-Hydroxypentyl)-1H-indol-3-yl](2-iodophenyl)-Methanone;Defluoro Hydroxy AM-694;AM694 N-(5-hydroxypentyl) metabolite
• CAS NO: 335160-94-6
• Molecular Formula: C20H20INO2
• Molecular Weight: 433.28277
• Product Categories: Agonists, Aromatics, Heterocycles, Indole Derivatives, Neurochemicals, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 335160-94-6.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 581.1±40.0 °C(Predicted)
• Appearance: /
• Density: 1.48±0.1 g/cm3(Predicted)
• PKA: 15.17±0.10(Predicted)
• CAS DataBase Reference: [1-(5-Hydroxypentyl)-1H-indol-3-yl](2-iodophenyl)-Methanone(CAS DataBase Reference)
• NIST Chemistry Reference: [1-(5-Hydroxypentyl)-1H-indol-3-yl](2-iodophenyl)-Methanone(335160-94-6)
• EPA Substance Registry System: [1-(5-Hydroxypentyl)-1H-indol-3-yl](2-iodophenyl)-Methanone(335160-94-6)

Safety Data

• Hazardous Substances Data: 335160-94-6(Hazardous Substances Data)

Usage

Description

[1-(5-Hydroxypentyl)-1H-indol-3-yl](2-iodophenyl)-Methanone is a complex organic compound with a molecular structure that features a 1H-indol-3-yl group connected to a 5-hydroxypentyl chain and a 2-iodophenyl group. It is a pale brown solid and serves as an intermediate in the preparation of AM-694, a potent synthetic cannabinoid with high affinity for both CB1 and CB2 receptors.

Uses

1. Used in Pharmaceutical Industry:
[1-(5-Hydroxypentyl)-1H-indol-3-yl](2-iodophenyl)-Methanone is used as an intermediate in the synthesis of AM-694 (A575825) for its potent agonist activity at both central CB1 and peripheral CB2 receptors. [1-(5-Hydroxypentyl)-1H-indol-3-yl](2-iodophenyl)-Methanone is valuable in the development of therapeutic agents targeting the endocannabinoid system, which plays a crucial role in various physiological processes and has potential applications in treating a range of conditions, including pain, inflammation, and neurodegenerative diseases.
2. Used in Forensic Applications:
[1-(5-Hydroxypentyl)-1H-indol-3-yl](2-iodophenyl)-Methanone, as an intermediate in the preparation of AM-694, is also utilized in forensic science for the detection and identification of synthetic cannabinoids in biological samples. This is particularly important in cases where the presence of these substances may be relevant to legal or medical investigations.
3. Used in Research Applications:
[1-(5-Hydroxypentyl)-1H-indol-3-yl](2-iodophenyl)-Methanone is employed in research settings to study the pharmacological effects of synthetic cannabinoids, particularly AM-694, on the endocannabinoid system. This research can contribute to a better understanding of the system's role in various physiological and pathological processes, potentially leading to the development of new therapeutic strategies and treatments for a variety of conditions.