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335207-81-3

2-cyano-N-(4'-methoxybenzyl)-3-(2-methyl-1H-indol-3-yl)acrylamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 335207-81-3 Structure

  • Basic information

    1. Product Name: 2-cyano-N-(4'-methoxybenzyl)-3-(2-methyl-1H-indol-3-yl)acrylamide
    2. Synonyms: 2-cyano-N-(4'-methoxybenzyl)-3-(2-methyl-1H-indol-3-yl)acrylamide
    3. CAS NO:335207-81-3
    4. Molecular Formula:
    5. Molecular Weight: 345.401
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 335207-81-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-cyano-N-(4'-methoxybenzyl)-3-(2-methyl-1H-indol-3-yl)acrylamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-cyano-N-(4'-methoxybenzyl)-3-(2-methyl-1H-indol-3-yl)acrylamide(335207-81-3)
    11. EPA Substance Registry System: 2-cyano-N-(4'-methoxybenzyl)-3-(2-methyl-1H-indol-3-yl)acrylamide(335207-81-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 335207-81-3(Hazardous Substances Data)

335207-81-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 335207-81-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,3,5,2,0 and 7 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 335207-81:
(8*3)+(7*3)+(6*5)+(5*2)+(4*0)+(3*7)+(2*8)+(1*1)=123
123 % 10 = 3
So 335207-81-3 is a valid CAS Registry Number.

335207-81-3Downstream Products

335207-81-3Relevant articles and documents

Inhibition of dynamin mediated endocytosis by the Dynoles - Synthesis and functional activity of a family of indoles

Hill, Timothy A.,Gordon, Christopher P.,McGeachie, Andrew B.,Venn-Brown, Barbara,Odell, Luke R.,Chau, Ngoc,Quan, Annie,Mariana, Anna,Sakoff, Jennette A.,Chircop, Megan,Robinson, Phillip J.,McCluskey, Adam

experimental part, p. 3762 - 3773 (2010/04/24)

Screening identified two bisindolylmaleimides as 100 μM inhibitors of the GTPase activity of dynamin I. Focused library approaches allowed development of indole-based dynamin inhibitors called dynoles. 100-Fold in vitro enhancement of potency was noted with the best inhibitor, 2-cyano-3-(1-(2- (dimethylamino)ethyl)-1H-indol-3-yl)-N-octylacrylamide (dynole 34-2), a 1.3 ± 0.3 μM dynamin I inhibitor. Dynole 34-2 potently inhibited receptor mediated endocytosis (RME) internalization of Texas red-transferrin. The rank order of potency for a variety of dynole analogues on RME in U2OS cells matched their rank order for dynamin inhibition, suggesting that the mechanism of inhibition is via dynamin. Dynoles are the most active dynamin I inhibitors reported for in vitro or RME evaluations. Dynole 34-2 is 15-fold more active than dynasore against dynamin I and 6-fold more active against dynamin mediated RME (IC50 ～15 μM; RME IC50 ～80 μM). The dynoles represent a new series of tools to better probe endocytosis and dynamin-mediated trafficking events in a variety of cells.

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