335256-91-2

Upstream product

• 335255-84-0 3-(3-Imidazol-1-yl-phenyl)-3-oxo-propionic Acid tert-butyl Ester 
• 335255-65-7 tert-butyl 3-amino-2’-fluorobiphenyl-4-ylcarbamate 
• 335256-34-3 6-(3-imidazol-1-yl-phenyl)-2,2-dimethyl-[1,3]dioxin-4-one 

Downstream Products

• 335258-22-5 8-(2-Fluoro-phenyl)-4-(3-imidazol-1-yl-phenyl)-1,3-dihydro-benzo [b][1,4]diazepin-2-one 

Relevant academic research and scientific papers

Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 3. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists

A series of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives was evaluated as non-competitive mGluR2/3 antagonists. Replacement of the (2-aryl)-ethynyl-moiety in 8-position with smaller less lipophilic substituents produced compounds inhibiting the bin

Glutamate receptor antagonists

The present invention is a compound of formula wherein X is an ethynediyl group, R1, R2and R3are as defined in the specification.