335258-64-5Relevant academic research and scientific papers
Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 3. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists
Woltering, Thomas J.,Wichmann, Juergen,Goetschi, Erwin,Adam, Geo,Kew, James N.C.,Knoflach, Frederic,Ballard, Theresa M.,Huwyler, Joerg,Mutel, Vincent,Gatti, Silvia
, p. 2725 - 2729 (2008/12/21)
A series of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives was evaluated as non-competitive mGluR2/3 antagonists. Replacement of the (2-aryl)-ethynyl-moiety in 8-position with smaller less lipophilic substituents produced compounds inhibiting the bin
Glutamate receptor antagonists
-
, (2008/06/13)
The present invention is a compound of formula wherein X is an ethynediyl group, R1, R2and R3are as defined in the specification.
