33533-46-9Relevant academic research and scientific papers
ISOINDOLE DERIVATIVES
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Page/Page column 43, (2010/11/30)
This invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, a process of making these compounds, pharmaceutical compositions containing one or more of these compounds or their salts, and their use for the treatment of schizophrenia, bipolar disorder, or other central nervous system disorders.
Heterosubstituted or functionalized derivatives of 1- and 2-(trifluoro-methyl)naphthalenes emanating from aryne adducts
Bailly, Frederic,Gottet, Fabrice,Schlosser, Manfred
, p. 791 - 797 (2007/10/03)
More than two dozen new CF3-substituted naphthalene derivatives were prepared in an expedient way by employing 3- and 4-(trifluoromethyl)benzyne as the key intermediates. 2- and 4-Chlorobenzotrifluoride were treated with butyllithium and the organometallic species thus generated were allowed to decompose in the presence of furan. The resulting cycloadducts 1 and 14 were reduced to the (trifluoromethyl)naphthalenes 2 and 15, ring- opened to the (trifluoromethyl)naphthols 3,16 and 17 and transformed to the dibromo adducts 5 and 18. The latter were stereoselectively converted into the bromo-1,4-epoxy-1,4-dihydro(trifluoromethyl)naphthalenes 6,7,19 and 20 and, by deoxygenation, into various bromo(trifluoromethyl)naphthalenes 8, 9, 21 and 22. Trifluoromethyl substituted naphthoic acids 10-13 and 23-26 were obtained when the bromo compounds 6-9 and 19-22 were subjected to a halogen/metal permutation followed by carboxylation.
