335334-63-9Relevant academic research and scientific papers
Bis(sulfonamide) transmembrane carriers allow pH-gated inversion of ion selectivity
Roy, Arundhati,Biswas, Oindrila,Talukdar, Pinaki
, p. 3122 - 3125 (2017)
Bis(sulfonamide) based synthetic carriers are reported for inversion of ion selectivity upon deviation of pH within a narrow window. A liposomal membrane potential is also generated when potassium ions are passively transported by these carriers.
Aryl Bis-Sulfonamide Inhibitors of IspF from Arabidopsis thaliana and Plasmodium falciparum
Thelemann, Jonas,Illarionov, Boris,Barylyuk, Konstantin,Geist, Julie,Kirchmair, Johannes,Schneider, Petra,Anthore, Lucile,Root, Katharina,Trapp, Nils,Bacher, Adelbert,Witschel, Matthias,Zenobi, Renato,Fischer, Markus,Schneider, Gisbert,Diederich, Fran?ois
supporting information, p. 2090 - 2098 (2015/12/23)
2-Methylerythritol 2,4-cyclodiphosphate synthase (IspF) is an essential enzyme for the biosynthesis of isoprenoid precursors in plants and many human pathogens. The protein is an attractive target for the development of anti-infectives and herbicides. Using a photometric assay, a screen of 40 000 compounds on IspF from Arabidopsis thaliana afforded symmetrical aryl bis-sulfonamides that inhibit IspF from A. thaliana (AtIspF) and Plasmodium falciparum (PfIspF) with IC50 values in the micromolar range. The ortho-bis-sulfonamide structural motif is essential for inhibitory activity. The best derivatives obtained by parallel synthesis showed IC50 values of 1.4 μm against PfIspF and 240 nm against AtIspF. Substantial herbicidal activity was observed at a dose of 2 kg ha-1. Molecular modeling studies served as the basis for an in silico search targeted at the discovery of novel, non-symmetrical sulfonamide IspF inhibitors. The designed compounds were found to exhibit inhibitory activities in the double-digit micromolar IC50 range.
Urea-, squaramide-, and sulfonamide-based anion receptors: A thermodynamic study
Amendola, Valeria,Fabbrizzi, Luigi,Mosca, Lorenzo,Schmidtchen, Franz-Peter
supporting information; experimental part, p. 5972 - 5981 (2011/07/07)
In this work, we compare the anion-binding capabilities of receptors 1-5, characterized by similar structures, but possessing different hydrogen-bond-donor moieties (urea, squaramide, and sulfonamide). The presence of chromophoric substituents on the receptor's skeleton allowed the determination of association constants by performing UV/Vis titrations with the investigated anions on solutions of the receptors in pure acetonitrile. Additional quantitative studies of the anion-binding properties of receptors 1-5 were performed by isothermal titration calorimetry (ITC). The experimental results indicated that 1 and 2 formed 1:1 hydrogen-bonded complexes with most of the anions investigated. In the case of receptors 3-5, the formation of the 1:1 adduct was observed only with anions of low basicity (i.e., chloride, bromide, iodide, and hydrogen sulfate). With more basic anions (i.e., acetate and dihydrogen phosphate), both spectrophotometric and ITC titrations accounted for the deprotonation of the sulfonamide group, involving the formation of the conjugated base of the receptor. Copyright
