335337-39-8Relevant academic research and scientific papers
A novel synthesis of didehydroamino acid esters from azomethine ylides
Groundwater, Paul W.,Sharif, Toqir,Arany, Andrea,Hibbs, David E.,Hursthouse, Michael B.,Garnett, Ian,Nyerges, Miklos
, p. 2837 - 2846 (1998)
A novel synthesis of didehydroamino acid (DDAA) esters 5 is described, starting from aldimines 2. The mechanism for this reaction has been shown to involve the cycloaddition of an azomethine ylide 3 to an imine 2, followed by the base-catalysed ring-opening of the resulting imidazolidine intermediate 7. This novel method has also been extended to the synthesis of DDAA esters 5 catalysed by imines.
