335350-94-2Relevant academic research and scientific papers
Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: New potent non-competitive metabotropic glutamate receptor 2/3 antagonists. Part 1
Woltering, Thomas J.,Adam, Geo,Alanine, Alexander,Wichmann, Juergen,Knoflach, Frederic,Mutel, Vincent,Gatti, Silvia
, p. 6811 - 6815 (2007)
A series of 1,3-dihydrobenzo[b][1,4]diazepin-2-one derivatives was evaluated as non-competitive mGluR2/3 antagonists. Attachment of an 8-(2-aryl)-ethynyl-moiety produced compounds inhibiting the binding of [3H]-LY354740 to rat mGluR2 with low n
Glutamate receptor antagonists
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, (2008/06/13)
The present invention relates to compounds of with a base structure of formula 1 The compounds of formula I are shown to have activity as metabotropic glutamate receptor antagonists.
