33538-64-6

Usage

Chemical Class

The compound belongs to the class of antibiotics known as venturicidins.

Derivative

It is a derivative of venturicidin B.

Deoxy Sugar Moiety

The compound contains a deoxy sugar moiety attached at the 13th position.

Antibacterial Activity

The compound exhibits potent antibacterial activity against a wide range of Gram-positive bacteria, including multidrug-resistant strains.

Mechanism of Action

The mechanism of action of the compound involves inhibiting bacterial cell wall synthesis by targeting lipid II, a crucial component in the formation of the peptidoglycan layer.

Potential Use

The compound shows promise as a potential lead compound for the development of new antibiotics to combat antibiotic-resistant bacterial infections.

Upstream product

• 129117-38-0 Acetic acid (9E,15E)-(1R,5S,6R,8R,11R,17R)-5-((1R,3R,4S,5S)-4-hydroxy-1,3,5-trimethyl-6-oxo-octyl)-1-methoxy-6,8,16,18-tetramethyl-3-oxo-4,21-dioxa-bicyclo[15.3.1]henicosa-9,15,18-trien-11-yl ester 
• 129117-38-0 Acetic acid (9E,15E)-(1R,5S,6R,8R,11S,17R)-5-((1R,3R,4S,5S)-4-hydroxy-1,3,5-trimethyl-6-oxo-octyl)-1-methoxy-6,8,16,18-tetramethyl-3-oxo-4,21-dioxa-bicyclo[15.3.1]henicosa-9,15,18-trien-11-yl ester 
• 129117-37-9 Acetic acid (9E,15E)-(1R,5S,6R,8R,11S,17R)-5-((1R,3R,4S,5R,6S)-4,6-dihydroxy-1,3,5-trimethyl-octyl)-1-methoxy-6,8,16,18-tetramethyl-3-oxo-4,21-dioxa-bicyclo[15.3.1]henicosa-9,15,18-trien-11-yl ester 
• 129117-36-8 (9E,15E)-(1R,5S,6R,8R,11S,17R)-5-[(1R,3R)-3-((4S,5R,6S)-6-Ethyl-2,2,5-trimethyl-[1,3]dioxan-4-yl)-1-methyl-butyl]-11-hydroxy-1-methoxy-6,8,16,18-tetramethyl-4,21-dioxa-bicyclo[15.3.1]henicosa-9,15,18-trien-3-one 
• 129117-27-7 (3R,5R,6R)-6-((1R,3R)-1,3-Dimethyl-pent-4-enyl)-3,5-dimethyl-tetrahydro-pyran-2-one 
• 129117-33-5 C₄₆H₈₅O₁₁PSi 
• 129136-04-5 C₄₀H₇₁O₁₁P 
• 129117-34-6 (9E,15E)-(1R,5S,6R,8R,17R)-5-[(1R,3R)-3-((4S,5R,6S)-6-Ethyl-2,2,5-trimethyl-[1,3]dioxan-4-yl)-1-methyl-butyl]-1-methoxy-6,8,16,18-tetramethyl-4,21-dioxa-bicyclo[15.3.1]henicosa-9,15,18-triene-3,11-dione 
• 129117-32-4 Acetic acid (1S,2R,4R)-5-(tert-butyl-dimethyl-silanyloxy)-1-[(1R,3R)-3-((4S,5R,6S)-6-ethyl-2,2,5-trimethyl-[1,3]dioxan-4-yl)-1-methyl-butyl]-2,4-dimethyl-pentyl ester 
• 121103-82-0 (2R,3R,4R,6R)-2,4,6-Trimethyl-1-trityloxy-oct-7-en-3-ol 
• 129117-31-3 Acetic acid (1S,2R,4R,5S,6R,7S)-1-[(1R,3R)-4-(tert-butyl-dimethyl-silanyloxy)-1,3-dimethyl-butyl]-5,7-dihydroxy-2,4,6-trimethyl-nonyl ester 
• 129117-29-9 Acetic acid (1S,2R,4R,5S,6R)-1-[(1R,3R)-4-(tert-butyl-dimethyl-silanyloxy)-1,3-dimethyl-butyl]-5-hydroxy-2,4,6-trimethyl-oct-7-enyl ester 
• 129117-22-2 (4S,5R,6S)-4-<(1R,3R,4S,5R,7R)-8-(tert-Butyldimethylsilyloxy)-4-hydroxy-1,3,5,7-tetramethyloctyl>-6-ethyl-2,2,5-trimethyl-1,3-dioxane 
• 129117-25-5 (4R,5S,6R,8R)-5-(tert-Butyl-dimethyl-silanyloxy)-4,6,8-trimethyl-dec-9-enoic acid tert-butyl ester 

Relevant academic research and scientific papers

Total synthesis of the aglycone of venturicidins A and B. II

The C15-C27 segment 2 of the aglycone 3 of venturicidins A and B was synthesized and then total synthesis of 3 was accomplished via intramolecular Wittig-Horner reaction of the ester from 2 and the previously synthesized C1-C14 segment 1.