335418-35-4

Upstream product

• 505095-32-9 (3R,4R,5R)-4-Acetylamino-3-isopropoxy-5-[2-(4-nitro-phenylselanyl)-ethyl]-cyclohex-1-enecarboxylic acid methyl ester 
• 216662-57-6 (1S,3R,4R,5R)-3,4-O-Benzylidene-1,3,4-trihydroxy-6-oxabicyclo<3.2.1>octan-7-one 
• 77-95-2 D-(-)-quinic acid 
• 105539-78-4 (1R,3S,4S,5R)-3-bromo-1-hydroxy-7-oxo-6-oxabicyclo[3.2.1]oct-4-yl benzoate 
• 183474-89-7 (1S,3S,4R,5R)-3-allyl-1-hydroxy-7-oxo-6-oxabicyclo[3.2.1]oct-4-yl benzoate 
• 335417-38-4 methyl (1R,5S,6S)-5-allyl-7-oxabicyclo[4.1.0]hept-2-ene-3-carboxylate 
• 335417-45-3 methyl (1S,5S,6R)-5-allyl-7-azabicyclo[4.1.0]hept-2-ene-3-carboxylate 
• 335417-41-9 methyl (3S,4S,5S)-5-allyl-3-azido-4-hydroxy-1-cyclohexene-1-carboxylate 
• 335418-32-1 methyl (3R,4R,5R)-4-(acetylamino)-3-isopropoxy-5-{2-[(2-nitrophenyl)selanyl]ethyl}-1-cyclohexene-1-carboxylate 
• 335417-88-4 methyl (3R,4R,5R)-4-(acetylamino)-5-(2-hydroxyethyl)-3-isopropoxy-1-cyclohexene-1-carboxylate 
• 335417-50-0 methyl (3R,4R,5S)-4-(acetylamino)-5-allyl-3-isopropoxy-1-cyclohexene-1-carboxylate 
• 335417-43-1 methyl (3S,4S,5S)-5-allyl-3-azido-4-[(methylsulfonyl)oxy]-1-cyclohexene-1-carboxylate 
• 335417-32-8 (1R,2R,3S,5S)-3-allyl-5-(methoxycarbonyl)-2,5-bis[(methylsulfonyl)oxy]cyclohexyl benzoate 
• 335417-48-6 methyl (1S,5S,6R)-5-allyl-7-trityl-7-azabicyclo[4.1.0]hept-2-ene-3-carboxylate 

Relevant academic research and scientific papers

Neuraminidase inhibitors

The present invention provides compounds of formula Ia and Ib or a pharmaceutically acceptable salt, prodrug, or ester thereof, useful in the inhibition of neuraminidase enzymes from disease-causing microorganisms, especially influenza neuraminidase, phar

Design, synthesis, and neuraminidase inhibitory activity of GS-4071 analogues that utilize a novel hydrophobic paradigm.

Structure-based design has led to the synthesis of a novel analogue of GS-4071, an influenza neuraminidase inhibitor, in which the basic amino group has been replaced by a hydrophobic vinyl group. An X-ray co-crystal structure of the new inhibitor (K(i)=4