33543-78-1

Basic information

• Product Name: ETHYL IMIDAZOLE-2-CARBOXYLATE
• Synonyms: RARECHEM AL BI 0666;1H-IMIDAZOLE-2-CARBOXYLIC ACID ETHYL ESTER;ETHYL IMIDAZOLE-2-CARBOXYLATE;Imidazole-2-carboxylic acid ethyl ester;Ethyl 1H-imidazole-2-carboxylate;2-(Ethoxycarbonyl)-1H-imidazole;Ethyl 2-IMidazolecarboxylate;Ethylimidazole-2-carboxylate,97%
• CAS NO: 33543-78-1
• Molecular Formula: C₆H₈N₂O₂
• Molecular Weight: 140.14
• EINECS: -0
• Mol File: 33543-78-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 176-178°C
• Boiling Point: 48-51°C 0,3mm
• Flash Point: 48-51°C/0.3mm
• Appearance: /
• Density: 1.214 g/cm³
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 11.38±0.10(Predicted)
• BRN: 115685
• CAS DataBase Reference: ETHYL IMIDAZOLE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL IMIDAZOLE-2-CARBOXYLATE(33543-78-1)
• EPA Substance Registry System: ETHYL IMIDAZOLE-2-CARBOXYLATE(33543-78-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37
• Hazardous Substances Data: 33543-78-1(Hazardous Substances Data)

Usage

Chemical Properties

Light brown powder

Uses

Ethyl Imidazole-2-carboxylate is an intermediate used to synthesize tricyclic quinoxalinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1). It is also used to prepare imidazoindenopyrazinone carboxylic acid derivatives as AMPA antagonists with anticonvulsant activities.

Upstream product

• 865998-45-4 1-benzyl-1H-imidazole-2-carboxylic acid ethyl ester 
• 64-17-5 ethanol 
• 163769-73-1 2-(trichloromethyl)-1H-imidazole 

Downstream Products

• 865998-46-5 4-nitro-1H-imidazole-2-carboxylic acid ethyl ester 
• 327188-91-0 ethyl 1-[4-(4-chlorophenyl)-5-[3-(2-methoxyphenoxy)propyl]-2-oxazolyl]imidazole-2-carboxylate 
• 68251-67-2 imidazoyl acyl hydrazine 
• 202592-76-5 ethyl 1-[4-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]butyl]-2-imidazolecarboxylate 
• 202592-80-1 ethyl 1-[3-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]propyl]-2-imidazolecarboxylate 
• 198064-78-7 ethyl 1-[4-[4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-oxazolyl]butyl)-2-imidazolecarboxylate 
• 67478-49-3 1-trityl-1H-imidazole-2-carboxylic acid ethyl ester 
• 920511-25-7 N-(3-fluorophenyl)-1-(1H-imidazol-2-ylcarbonyl)-4-piperidinamine 
• 920511-27-9 ethyl 1-(4-formylphenyl)-1H-imidazole-2-carboxylate 
• 162070-31-7 1-((6aR,9R,10aR)-7-Methyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinolin-9-ylmethyl)-1H-imidazole-2-carboxylic acid ethyl ester 

Relevant articles and documents

Orthogonally positioned diamino pyrrole- and imidazole-containing polyamides: Synthesis of 1-(3-substituted-propyl)-4-nitropyrrole-2-carboxylic acid and 1-(3-Chloropropyl)-4-nitroimidazole-2-carboxylic Acid

Pyrrole- and imidazole-containing polyamides can be tailored to recognize the DNA 6-8 base pair sequence. We found that adding a second amino group via the N1-position of pyrrole or imidazole in polyamides could enhance their DNA binding affinity and wate

CHEMICAL COMPOUNDS, COMPOSITIONS AND METHODS FOR KINASE MODULATION

Chemical compounds that modulate kinase activity, including PI3 kinase activity, and chemical compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

ANTIVIRAL 4-AMINOCARBONYLAMINO-SUBSTITUTED IMIDAZOLE COMPOUND

The invention relates to the substituted imidazoles of formula (I) and to methods for producing the same, to their use in the treatment and/or prophylaxis of diseases and to their use for producing drugs for use in the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, especially against cytomegaloviruses.