335444-22-9Relevant academic research and scientific papers
Design and synthesis of novel antibacterial agents with inhibitory activity against DNA polymerase III
Ali, Amjad,Aster, Susan D.,Graham, Donald W.,Patel, Gool F.,Taylor, Gayle E.,Tolman, Richard L.,Painter, Ronald E.,Silver, Lynn L.,Young, Katherine,Ellsworth, Kenneth,Geissler, Wayne,Harris, Georgianna S.
, p. 2185 - 2188 (2001)
4-Substituted 2-amino-6-(anilino)pyrimidines have been found to be selective inhibitors of DNA polymerase III, a replicative enzyme known to be essential in the DNA synthesis of Gram-positive bacteria. Among the analogues, 18 displayed an IC50 of 10 μM against DNA polymerase III from Staphylococcus aureus.
