3355-30-4Relevant academic research and scientific papers
Copper-catalyzed propargylation of diborylmethane
Li, Feng,Zhang, Zhen-Qi,Lu, Xi,Xiao, Bin,Fu, Yao
supporting information, p. 3551 - 3554 (2017/03/31)
A Cu/PPh3-catalyzed propargylic substitution reaction of diborylmethane is reported. Different substituted propargyl electrophiles can be employed in this reaction, and various synthetic valuable functional groups can be tolerated. Di-deuterate
Copper-catalyzed nucleophilic trifluoromethylation of propargylic halides
Miyake, Yoshihiro,Ota, Shin-Ichi,Shibata, Masashi,Nakajima, Kazunari,Nishibayashi, Yoshiaki
supporting information, p. 7809 - 7811 (2013/09/02)
Reactions of propargylic halides with trifluoromethyltrimethylsilane in the presence of a catalytic amount of copper(i) thiophene-2-carboxylate (CuTC) have been found to give the corresponding trifluoromethylated products in good to high yields with a hig
Direct conversion of carbonyl compounds into organic halides: Indium(III) hydroxide-catalyzed deoxygenative halogenation using chlorodimethylsilane
Onishi, Yoshiyuki,Ogawa, Daigo,Yasuda, Makoto,Baba, Akio
, p. 13690 - 13691 (2007/10/03)
The reaction of carbonyls and chlorodimethylsilane was effectively catalyzed by indium(III) hydroxide and afforded the corresponding deoxygenative chlorination products, in which the carbonyl carbon accepted two nucleophiles (H and Cl) with releasing oxygen. Only In(OH)3 catalyzed the reaction, and typical Lewis acids such as TiCl4, AlCl3, and BF3·OEt2 showed no catalytic activity. The reaction mechanism of this deoxygenative chlorination includes initial hydrosilylation followed by chlorination. Other nucleophiles such as allyl or iodine were available for this methodology. The moderate Lewis acidity of indium catalyst enabled chemoselective reaction, and therefore ester, nitro, cyano, or halogen groups were not affected during the reaction course. Copyright
