33554-72-2

Usage

Uses

Used in Textile Industry:
(E)-(4-chlorophenyl)diazenecarbonitrile is used as a key intermediate for the production of azo dyes and pigments in the textile industry. Its application is primarily due to its ability to impart vibrant colors and hues to fabrics, enhancing their visual appeal and durability.
Used in Chemical Synthesis:
DNCB is also employed as a crucial component in the synthesis of other chemical compounds. Its versatile chemical structure allows for its use in creating a wide range of products, contributing to its significance in the chemical industry.
Used in Dye and Pigment Production:
(E)-(4-chlorophenyl)diazenecarbonitrile is used as a raw material in the production of dyes and pigments. Its application in this industry is driven by its capacity to produce a diverse array of colors, making it a valuable asset for creating visually striking and long-lasting dyes and pigments.

Upstream product

• 106-47-8 4-chloro-aniline 

Relevant academic research and scientific papers

Arylazoamidoximes and related compounds as NO-modulators

Three amidinoarylhydrazines 1, three arylazoamidines 2, and nine arylazoamidoximes 3 have been synthesized and investigated for their potential to function as nitric oxide (NO) modulators. In-vitro studies demonstrated that 2 and 3 inhibited platelet aggregation (2c, IC50 = 3 μM) which could also be shown in vivo by inhibition of thrombus formation in arterioles (3a, 22%). Moreover, for all compounds antihypertensive effects were examined in vivo with SHR rats, with 2a being the most potent candidate by lowering blood pressure by 19%. However, no common underlying mechanism of action could be shown. Some of these compounds released HNO non-enzymatically. Incubations with NO synthase isoforms (NOSs) revealed, that compounds 1 to 3 were weak substrates for NOSs but arylazoamidoximes 3 remarkably elevated the NOSs activity in the presence of L-arginine (3h, up to fivefold). In addition, we examined effects on arginase and dimethylarginine dimethylaminohydrolase (DDAH), two further enzymes involved in the complex regulation of NO biosynthesis, to elucidate whether the observed in-vivo effects can be traced back to their modulation. Furthermore, the metabolic fate of arylazoamidoximes 3 was addressed by investigation of a possible N-reductive biotransformation. In summary, novel NO-modulating compound classes are presented, among which arylazoamidoximes 3 are potent activators of NOS isoforms, and arylazoamidines 2 exert in-vivo effects by unknown mechanisms.