335590-64-2Relevant academic research and scientific papers
Synthesis, characterization, and metal coordinating ability of multifunctional carbohydrate-containing compounds for Alzheimer's therapy
Storr, Tim,Merkel, Michael,Song-Zhao, George X.,Scott, Lauren E.,Green, David E.,Bowen, Meryn L.,Thompson, Katherine H.,Patrick, Brian O.,Schugar, Harvey J.,Orvig, Chris
, p. 7453 - 7463 (2008/02/06)
Dysfunctional interactions of metal ions, especially Cu, Zn, and Fe, with the amyloid-β (Aβ) peptide are hypothesized to play an important role in the etiology of Alzheimer's disease (AD). In addition to direct effects on Aβ aggregation, both Cu and Fe ca
Synthesis and antiperoxidant activity of new phenolic O-glycosides
Ponticelli, Fabio,Trendafilova, Antoaneta,Valoti, Massimo,Saponara, Simona,Sgaragli, GianPietro
, p. 459 - 468 (2007/10/03)
We describe the synthesis of some 3-tert-butyl-4-hydroxyphenyl D-glycopyranosides by reaction of tert-butylhydroquinone with β-D-pentaacetyl-glucose, β-D-pentaacetyl-galactose, 2-acetamido- and 3,4,6-tri-O-acetyl-2-butanamido-2-deoxy-β-D-glucopyranosyl chlorides as well as the formation of anomeric 3-tert-butyl-4-hydroxyphenyl 4,6-di-O-acetyl-2,3-dideoxy-D-erythro-hex-2-eno-pyranosides by reaction between tert-butylhydroquinone and 3,4,6-tri-O-acetyl-D-glucal. All compounds, except 3-tert-butyl-4-hydroxyphenyl α- and β-D-glucopyranosides, inhibited lipid peroxidation with a degree of potency comparable to that of tert-butyl hydroxyanisole.
