33561-24-9

Usage

Uses

Used in Pharmaceutical Synthesis:
3-Amino-4,4,4-trifluoro-2-butenenitrile is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of novel drug molecules with enhanced properties.
Used in Agrochemical Production:
In the agrochemical industry, 3-Amino-4,4,4-trifluoro-2-butenenitrile is utilized as a building block in the creation of new agrochemicals, potentially leading to more effective and targeted pest control solutions.
Used in Organic Chemistry Research:
3-Amino-4,4,4-trifluoro-2-butenenitrile serves as a versatile reagent in organic chemistry, facilitating the exploration of new reactions and the synthesis of complex organic molecules.
Used in Material Science:
Due to its distinctive properties, 3-Amino-4,4,4-trifluoro-2-butenenitrile is employed in material science for the development of advanced materials with specific characteristics, such as improved stability or reactivity.
It is crucial to handle 3-Amino-4,4,4-trifluoro-2-butenenitrile with care, as it may possess toxic or hazardous effects. Adequate safety measures and precautions should be strictly followed during its use in any application.

Upstream product

• 110234-68-9 3-cyano-1,1,1-trifluoroacetone 

Downstream Products

• 1015077-71-0 4-(4-Cyano-2-methoxyphenyl)-6-methyl-5-(4-methyl-1,3-thiazol-2-yl)-2-(trifluoromethyl)-1,4-di-hydropyridine-3-carbonitrile 
• 1015077-77-6 4-(4-Cyano-2-methoxyphenyl)-6-(methoxymethyl)-5-(4-methyl-1,3-thiazol-2-yl)-2-(trifluoromethyl)-1,4-dihydropyridine-3-carbonitrile 
• 1015077-78-7 4-(4-Cyano-2-methoxyphenyl)-6-ethyl-5-(4-methyl-1,3-thiazol-2-yl)-2-(trifluoromethyl)-1,4-dihydro-pyridine-3-carbonitrile 
• 1311135-25-7 4-(3-methyl-1H-indazol-5-yl)-2-phenyl-6-(trifluoromethyl)-1,4-dihydropyridine-3,5-dicarbonitrile 
• 1309048-36-9 N-[2-(3-cyano-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridin-4-yl)furo[3,2-c]pyridin-4-yl]benzamide 
• 1210047-35-0 1-(2-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-amine 

Relevant academic research and scientific papers

Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers

SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily A member 2 (SMARCA2), also known as Brahma homologue (BRM), is a Snf2-family DNA-dependent ATPase. BRM and its close homologue Brahma-related gene 1 (BRG1), also known as SMARCA4, are mutually exclusive ATPases of the large ATP-dependent SWI/SNF chromatin-remodeling complexes involved in transcriptional regulation of gene expression. No small molecules have been reported that modulate SWI/SNF chromatin-remodeling activity via inhibition of its ATPase activity, an important goal given the well-established dependence of BRG1-deficient cancers on BRM. Here, we describe allosteric dual BRM and BRG1 inhibitors that downregulate BRM-dependent gene expression and show antiproliferative activity in a BRG1-mutant-lung-tumor xenograft model upon oral administration. These compounds represent useful tools for understanding the functions of BRM in BRG1-loss-of-function settings and should enable probing the role of SWI/SNF functions more broadly in different cancer contexts and those of other diseases.