335665-84-4

Basic information

• Product Name: 3-{(2S)-4-cyclopropyl-1,1,1-trifluoro-2-[(2-fluoro-6-methoxybenzyl)oxy]but-3-yn-2-yl}-5-ethyl-6-methylpyridin-2(1H)-one
• CAS NO: 335665-84-4
• Molecular Formula: C₂₃H₂₃F₄NO₃
• Molecular Weight: 437.4272
• Mol File: 335665-84-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 545.6°C at 760 mmHg
• Flash Point: 283.8°C
• Density: 1.29g/cm³
• Vapor Pressure: 5.83E-12mmHg at 25°C
• Refractive Index: 1.543
• CAS DataBase Reference: 3-{(2S)-4-cyclopropyl-1,1,1-trifluoro-2-[(2-fluoro-6-methoxybenzyl)oxy]but-3-yn-2-yl}-5-ethyl-6-methylpyridin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-{(2S)-4-cyclopropyl-1,1,1-trifluoro-2-[(2-fluoro-6-methoxybenzyl)oxy]but-3-yn-2-yl}-5-ethyl-6-methylpyridin-2(1H)-one(335665-84-4)
• EPA Substance Registry System: 3-{(2S)-4-cyclopropyl-1,1,1-trifluoro-2-[(2-fluoro-6-methoxybenzyl)oxy]but-3-yn-2-yl}-5-ethyl-6-methylpyridin-2(1H)-one(335665-84-4)

Safety Data

• Hazardous Substances Data: 335665-84-4(Hazardous Substances Data)

Upstream product

• 335665-38-8 4-cyclopropyl-2-(5-ethyl-2-methoxy-6-methyl-pyridin-3-yl)-1,1,1-trifluoro-but-3-yn-2-ol 
• 335665-34-4 1-(5-ethyl-2-methoxy-6-methyl-pyridin-3-yl)-2,2,2-trifluoro-ethanone 
• 136562-05-5 5-ethyl-2-methoxy-6-methylpyridine-3-carboxaldehyde 

Relevant articles and documents

Trifluoromethyl-containing 3-alkoxymethyl- and 3-aryloxymethyl-2-pyridinones are potent inhibitors of HIV-1 non-nucleoside reverse transcriptase

3-Alkoxymethyl- and 3-aryloxymethyl-2-pyridinones were synthesized and evaluated for activity as non-nucleoside reverse transcriptase inhibitors (NNRTIs) of HIV-1. It was found that several compounds were potent inhibitors of HIV-1 with the most potent compound 24 exhibiting an IC90 = 32 nM. Compound 24 also possessed a potent resistance profile as demonstrated by submicromolar IC90s against several clinically meaningful mutant virus strains.