335665-98-0Relevant academic research and scientific papers
Trifluoromethyl-containing 3-alkoxymethyl- and 3-aryloxymethyl-2-pyridinones are potent inhibitors of HIV-1 non-nucleoside reverse transcriptase
Corbett, Jeffrey W.,Kresge, Kristen J.,Pan, Senliang,Cordova, Beverly C.,Klabe, Ronald M.,Rodgers, James D.,Erickson-Viitanen, Susan K.
, p. 309 - 312 (2007/10/03)
3-Alkoxymethyl- and 3-aryloxymethyl-2-pyridinones were synthesized and evaluated for activity as non-nucleoside reverse transcriptase inhibitors (NNRTIs) of HIV-1. It was found that several compounds were potent inhibitors of HIV-1 with the most potent compound 24 exhibiting an IC90 = 32 nM. Compound 24 also possessed a potent resistance profile as demonstrated by submicromolar IC90s against several clinically meaningful mutant virus strains.
