335672-30-5

Usage

Class

Amines

Use

Potential antiretroviral agent for the treatment of HIV/AIDS

Mechanism of action

Blocks the entry of the virus into human cells by inhibiting the interaction between the virus and host cell receptors

Potential benefits

Prevents the spread of HIV in the body, reduces the development of drug-resistant strains of the virus

Other potential uses

Treatment of other viral infections, therapeutic agent in preclinical studies

Upstream product

• 1611449-79-6 1-(2-(piperidin-1-yl)ethoxy)-3,4-dinitrobenzene 
• 2008-75-5 N-chloroethylpiperidine hydrochloride 
• 577-71-9 3,4-dinitophenol 

Downstream Products

• 1611449-80-9 C₄₁H₅₅N₅O₅ 

Relevant academic research and scientific papers

Salphen metal complexes as tunable G-quadruplex binders and optical probes

A series of seven new metal complexes (metal = NiII, Cu II, PtII and VO2+) with substituted salphen ligands have been prepared and their duplex and G-quadruplex DNA affinities determined. The selectivity of the complexes towards a given DNA topology is dictated by several factors including geometry, overall charge and substitution pattern of the complex. We also show that the two platinum(II)-salphen complexes developed as part of this series are emissive. Confocal microscopy studies were carried out with these two complexes using four different cell lines (CHO, HeLa, U2OS and HepG2). These studies showed that the cell permeability and localization are different for the two probes and highly dependent on the cell line used.