33588-68-0

Upstream product

• 120-72-9 indole 
• 870-63-3 prenyl bromide 

Downstream Products

• 1236228-86-6 (Z)-1-benzyl-6-methyl-3-{[2-(3-methylbut-2-enyl)-1H-indol-3-yl]methylidene}-piperazine-2,5-dione 

Relevant academic research and scientific papers

Electrophilic allylations and benzylations of indoles in neutral aqueous or alcoholic solutions

(Chemical Equation Presented) Indoles are allylated and benzylated in moderate to quantitative yield when stirred with allyl and benzyl halides in 80% aqueous acetone in the presence of NH4HCO3 at room temperature.

Regioselective synthesis of 3-alkylindoles mediated by zinc triflate

Zinc triflate was found to be an effective reagent for the C3-alkylation of indoles by alkyl halides in the presence of Huenig's base and tetrabutylammonium iodide. This new method for indole alkylation proceeds by a SN1-like pathway, and is general for allylic, benzylic, and tertiary halides.