336105-28-3

Upstream product

• 196929-78-9 (R)-2-methylpropane-2-sulfinamide 
• 2043-61-0 cyclohexanecarbaldehyde 

Downstream Products

• 479480-54-1 ethyl (3R)-3-[(tert-butylsulfinyl)amino]-3-cyclohexyl-2,2-difluoropropanoate 
• 1029700-88-6 pinacol (R)-1-((R)-tert-butanesulfinamido)cyclohexylmethylboronate 
• 1428527-35-8 (R)-N-((R)-(4-bromophenyl)(cyclohexyl)methyl)-2-methylpropane-2-sulfinamide 
• 1428527-39-2 4-((R)-cyclohexyl(4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamido) methyl)phenyl(methyl)phosphinic acid 
• 1428527-38-1 ethyl 4-((R)-cyclohexyl(4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamido) methyl)phenyl(methyl)phosphinate 
• 1428527-36-9 ethyl 4-((R)-cyclohexyl((R)-1,1-dimethylethylsulfinamido)methyl)phenyl(methyl) phosphinate 
• 1429229-90-2 (R)-1-((R_S)-tert-butylsulfinyl)-2-cyclohexyl-4-methylenepyrrolidine 
• 1429230-04-5 (S)-1-((R_S)-tert-butylsulfinyl)-2-cyclohexyl-4-methylenepyrrolidine 
• 479480-60-9 N-[(3R)-3-cyclohexyl-3-({N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-phenylalanyl}amino)-2,2-difluoropropyl]-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolinamide 
• 479480-58-5 N-{(3R)-3-[(tert-butylsulfinyl)amino]-3-cyclohexyl-2,2-difluoropropyl}-1-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolinamide 
• 479480-66-5 methyl N-((3R)-3-{[(1-tert-butoxycarbonyl)-L-prolyl]amino}-3-cyclohexyl-2,2-difluoropropanoyl)-L-phenylalaninate 

Relevant academic research and scientific papers

High kinetic resolution in the addition of a racemic allenylzinc onto enantiopure N-tert-butanesulfinimines: Concise synthesis of enantiopure trans-2-ethynylaziridines

Enantiopure trans-ethynyl N-tert-butanesulfinylaziridines (RS)-6 were prepared in good to excellent yields by the condensation of the racemic allenylzinc species 1 derived from 3-chloro-1-trimethylsilylpropyne onto the corresponding enantiopure

SUBSTITUTED PYRIMIDINES

Disclosed are substituted pyrimidines useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.

SUBSTITUTED PYRIMIDINES

The present invention relates to substituted pyrimidines useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.

Cycloaddition of chiral tert -butanesulfinimines with trimethylenemethane

The cycloaddition of chiral tert-butanesulfinimines with trimethylenemethane is found to give facile access to methylene-pyrrolidines with good yields and diastereoselectivities. The full scope of the cycloaddition is explored, and a range of transformations of the formed methylenepyrrolidines to give a range of functionalized chiral pyrrolidines is presented.

Corey-Chaykovsky Reaction of Chiral Sulfinyl Imines: A Convenient Procedure for the Formation of Chiral Aziridines

The reaction of dimethylsulfonium methylide with a range of aromatic, heterocyclic and aliphatic tert-butylsulfinyl imines is presented. Aziridines were formed in 63-84% yield and 77-95% diastereomeric excess.

Asymmetric synthesis of alpha,alpha-difluoro-beta-amino acid derivatives from enantiomerically pure N-tert-butylsulfinimines.

Addition of the Reformatsky reagent derived from ethyl bromodifluoroacetate to alkyl- and aryl-substituted N-tert-butylsulfinimines furnishes beta-tert-butylsulfinamyl-beta-substituted alpha,alpha-difluoroproponiates in diastereomeric ratios ranging from 80:20 to 95:5. The diastereomers are easily separated and the enantiomerically pure, protected beta-amino esters are readily transformed to the corresponding acid, amide, and amine derivatives as useful synthons for medicinal chemistry targets.