336187-82-7

Basic information

• Product Name: C₁₆H₉Cl₂NO₂
• Synonyms: C₁₆H₉Cl₂NO₂
• CAS NO: 336187-82-7
• Molecular Weight: 318.159
• Mol File: 336187-82-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₉Cl₂NO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₉Cl₂NO₂(336187-82-7)
• EPA Substance Registry System: C₁₆H₉Cl₂NO₂(336187-82-7)

Safety Data

• Hazardous Substances Data: 336187-82-7(Hazardous Substances Data)

Upstream product

• 487-89-8 Indole-3-carboxaldehyde 

Downstream Products

• 1169869-54-8 C₂₀H₁₁Cl₂N₃O₄ 
• 1169869-55-9 C₂₂H₁₅Cl₂N₃O₄ 

Relevant articles and documents

Synthesis and evaluation of indole, pyrazole, chromone and pyrimidine based conjugates for tumor growth inhibitory activities - Development of highly efficacious cytotoxic agents

Based upon the lead compounds 10 and 11, a number of conjugates were synthesized by the combination of chromone-pyrimidine, chromone-indolinone, chromone-pyrazole, indole-pyrimidine, indole-indolinone and indole-pyrazole moieties. Evaluation of these compounds for tumor growth inhibitory activities over 60 human tumor cell lines provided highly efficacious compounds 15, 41, 43, 66, 69, and 72 with an average GI50 over all the 60 human tumor cell lines as 3.2 μM, 3.1 μM, 1.7 μM, 2.6 μM, 50.1 μM and 2.0 μM, respectively.