336193-93-2Relevant academic research and scientific papers
Asymmetric synthesis of 2-alkyl-3-thiazoline carboxylates: Stereochemistry of the MnO2-mediated oxidation of cis- and trans-2-alkyl-thiazolidine-(4R)-carboxylates
Fernandez, Xavier,Duach, Elisabet
, p. 1279 - 1286 (2007/10/03)
The asymmetric synthesis of a series of 3-thiazoline carboxylates, 2, was effected by MnO2 oxidation of the corresponding cis/trans thiazolidines, 1. The stereochemistry of the oxidation reaction was studied using NMR and chiral GC analyses. Compounds 2 were obtained with enantiomeric excesses (e.e.s) in the range of 40-100%.
Chemo- and regioselective synthesis of alkyl-3-thiazoline carboxylates
Fernandez, Xavier,Fellous, Roland,Lizzani-Cuvelier, Louisette,Loiseau, Michel,Duach, Elisabet
, p. 1519 - 1521 (2007/10/03)
The synthesis of a series of allyl substituted 3-thiazoline-carboxylates was carried out from the corresponding thiazolidines, by a MnO2-mediated oxidation reaction under mild conditions. The reaction was chemoselective towards the amine-imine oxidation and was also regioselective, affording the unsaturation at the 3-position of the heterocycle.
