3363-26-6Relevant academic research and scientific papers
Preparation of N-alkyl 2-pyridones via a lithium iodide promoted oto N-alkyl migration: Scope and mechanism
Tasker, Sarah Z.,Bosscher, Michael A.,Shandro, Christina A.,Ryu, Keun Ah,Snapper, Gregory S.,Utter, Jarrad M.,Anderson, Carolyn E.,Lanni, Erica L.,Ellsworth, Bruce A.
, p. 8220 - 8230,11 (2020/10/15)
An efficient and inexpensive LiI-promoted O- to N-alkyl migration of 2-benzyloxy-, 2-allyloxy-, and 2-propargyloxypyridines and heterocycles is reported. The reaction produces the corresponding N-alkyl 2-pyridones and analogues under green, solvent-free conditions in good to excellent yields (30 examples, 20-97% yield). This method has been shown to be intermolecular and requires heat and lithium cation to occur.
REACTION OF MALEOHYDRAZIDE WITH α,α'-DIBROMO-o-XYLENE AND BENZYL CHLORIDE
Lisitsyn, V. N.,Omar, Salakh Al' Khadzh,Krasnokutskii, S. N.
, p. 754 - 758 (2007/10/02)
1,4,6,11H-Pyridazinophthalazine-1,4-dione and a dimeric product were isolated during the reaction of α,α'-dibromo-o-xylene with maleohydrazide.The reaction of maleohydrazide with benzyl chloride leads to the formation of O-benzyl, N-benzyl and O,N-dibenzyl-substituted compounds.
