Extracts of Inula which contain tomentosin (33649-15-9) have been used for centuries in traditional medicine for the treatment of inflammation.1 It suppresses the production of inflammatory mediators in RAW264.7 cells by inhibiting NFkB activation.2 It induces telomere shortening and caspase-dependent apoptosis in cervical cancer cells3 and induces apoptosis in human osteosarcoma MG-63 cells4. It causes G2/M arrest and apoptosis in human melanoma cell lines.5

33649-15-9

Post Buying Request

Basic information
1. Product Name: Tomentosin
2. Synonyms: (3aR)-3,3aα,4,7,8,8aα-Hexahydro-7β-methyl-3-methylene-6-(3-oxobutyl)-2H-cyclohepta[b]furan-2-one;(3aα)-3-Methylene-6-(3-oxobutyl)-7β-methyl-3,3aα,4,7,8,8aα-hexahydro-2H-cyclohepta[b]furan-2-one;Tomentosin;Tomentosin (Parthenium);C09562
3. CAS NO:33649-15-9
4. Molecular Formula: C₁₅H₂₀O₃
5. Molecular Weight: 248.3175
6. EINECS: N/A
7. Product Categories: N/A
8. Mol File: 33649-15-9.mol
Chemical Properties
1. Melting Point: N/A
2. Boiling Point: 416.2°Cat760mmHg
3. Flash Point: 185.1°C
4. Appearance: /
5. Density: 1.08g/cm³
6. Vapor Pressure: 3.9E-07mmHg at 25°C
7. Refractive Index: 1.51
8. Storage Temp.: -20°C
9. Solubility: Soluble in DMSO (50 mg/ml)
10. Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 month.
11. CAS DataBase Reference: Tomentosin(CAS DataBase Reference)
12. NIST Chemistry Reference: Tomentosin(33649-15-9)
13. EPA Substance Registry System: Tomentosin(33649-15-9)
Safety Data
1. Hazard Codes: N/A
2. Statements: N/A
3. Safety Statements: N/A
4. WGK Germany:
5. RTECS:
6. HazardClass: N/A
7. PackingGroup: N/A
8. Hazardous Substances Data: 33649-15-9(Hazardous Substances Data)

Suppliers
Usage
Upstream product
Downstream Products

33649-15-9 Suppliers

Recommended suppliers

33649-15-9 Usage

References

Lu et al. (2012), Inula japonica extract inhibits mast cell-mediated allergic reaction and mast cell activation; Ethnopharmacol. 143 151 Park et al. (2014), Suppressive effect of tomentosin on the production of inflammatory mediators in RAW264.7 cells; Biol. Pharm. Bull., 37 1177 Merghoub et al. (2017), Tomentosin Induces Telomere Shortening and Caspase-Dependent Apoptosis in Cervical Cancer Cells; J. Cell Biochem., 118 1689 Lee et al. (2019), Tomentosin Displays Anti-Carcinogenic Effect in Human Osteosarcoma MG-63 Cells via the Induction of Intracellular Reactive Oxygen Species; Int. J. Mol. Sci., 20(6) 1508 Rozenblat et al. (2008), Induction of G2/M arrest and apoptosis by sesquiterpene lactones in human melanoma cell lines; Biochem. Pharmacol., 75 369

Check Digit Verification of cas no

The CAS Registry Mumber 33649-15-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,3,6,4 and 9 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 33649-15:
(7*3)+(6*3)+(5*6)+(4*4)+(3*9)+(2*1)+(1*5)=119
119 % 10 = 9
So 33649-15-9 is a valid CAS Registry Number.

InChI:InChI=1/C15H20O3/c1-9-8-14-13(11(3)15(17)18-14)7-6-12(9)5-4-10(2)16/h6,9,13-14H,3-5,7-8H2,1-2H3/t9-,13+,14+/m0/s1

33649-15-9Upstream product

33649-15-9Downstream Products

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 33649-15-9