336612-66-9Relevant academic research and scientific papers
Synthesis and biological activities of fused biheterocycles containing indole nucleus: Reactions of 3-(5′-substituted-3′-phenylindol-2′-yl)-4-amino-4, 5-dihydro-s-triazol-5-thiones
Patil,Biradar
, p. 929 - 935 (2007/10/03)
5-(5′-Substituted-3′-phenylindol-2′-yl)-2,3-dihydro-1,3, 4-oxadiazol-2-thiones la-d on reaction with hydrazine hydrate in ethanol give 3-(5′-substituted-3′-phenylindol-2′-yl)-4-amino-4, 5-dihydro-s-triazole-5-thiones 2a-d. These compounds on reaction with phenacyl bromide, chloroacetic acid, cyanogen bromide, carbon disulphide and various aromatic acids furnish 7H-6-phenyl-3-(5′-substituted-3′-phenylindol-2′-yl)-s- triazolo[3,4-b][1,3,4]thiadiazines 3a-d, 7H-3-(5′-substituted-3′phenylindol-2′-yl)-s-triazolo [3,4-b][1,3,4]thiadiazin-6(5H)-ones 4a-d, 6-amino-3-(5′-substituted-3′-phenylin-dol-2′-yl)-s- triazolo[3,4-b][1,3,4]thiadiazoles 5a-d, 3-(5′.substituted-3′-phenylindol-2′-yl)-s-triazolo[3,4-b] [1,3,4]thiadiazole-6(5H)thiones 6a-d and 6-substituted-3-(5′-substituted-3′-phenylindol-2′-yl)-s- triazolo[3,4-b][1,3,4] thiadiazoles 7a-t. The characterisation of synthesized compounds has been done on the basis of elemental analysis, IR, 1H NMR and mass spectral data. All the newly synthesized compounds have been screened for their antimicrobial, anthelminthic, anti-inflammatory and anti-catatonic activities.
