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Acesulfame-K price food additives manufacturers
Cas No: 33665-90-6
USD $ 3900.0-4000.0 / Kilogram 500 Kilogram 10 Metric Ton/Week Arshine Pharmaceutical Co., Limited Contact Supplier
ACESULFAME
Cas No: 33665-90-6
USD $ 1.0-1.0 / Gram 1 Gram 10000 Kilogram/Day Ningbo Qicheng Chemical Co.,Ltd. Contact Supplier
Acesulfame
Cas No: 33665-90-6
No Data 1 Gram 10 Metric Ton/Day Hangzhou KieRay Chem Co.,Ltd. Contact Supplier
Acesulfame Manufacturer/High quality/Best price/In stock
Cas No: 33665-90-6
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High quality 1,2,3-Oxathiazin-4(3H)-One, 6-Methyl-, 2,2-Dioxide supplier in China
Cas No: 33665-90-6
No Data 1 Kilogram 30 Metric Ton/Month Simagchem Corporation Contact Supplier
Acesulfame
Cas No: 33665-90-6
USD $ 5.0-30.0 / Kilogram 1 Kilogram 200 Metric Ton/Year Jinan Finer Chemical Co., Ltd Contact Supplier
Acesulfame CAS NO.33665-90-6
Cas No: 33665-90-6
USD $ 2.0-2.0 / Gram 100 Gram 100 Metric Ton/Month Hebei yanxi chemical co.,LTD. Contact Supplier
Food grade Acesulfame CAS 33665-90-6
Cas No: 33665-90-6
USD $ 25.6-28.5 / Kilogram 1 Kilogram 10000 Kilogram/Year Xi'an Quanao Biotech Co., Ltd. Contact Supplier
Factory Price 99% Food Grade Acesulfame 33665-90-6 Kosher Manufacturer
Cas No: 33665-90-6
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier
Factory Supply high qualtiy 1,2,3-Oxathiazin-4(3H)-One, 6-Methyl-, 2,2-Dioxide
Cas No: 33665-90-6
No Data 1 1 Ality Chemical Corporation Contact Supplier

33665-90-6 Usage

Definition

ChEBI: A sulfamate ester that is 1,2,3-oxathiazin-4(3H)-one 2,2-dioxide substituted by a methyl group at position 6.

Toxicity

ADI 0-15 (FAO/WHO, 2001). Being safe to be used in food products (FDA, §172.800, 2000).

References

[1] https://www.fda.gov [2] Wei-na Cong, Rui Wang, Huan Cai, Caitlin M. Daimon, Morten Scheibye-Knudsen, Vilhelm A. Bohr, Rebecca Turkin, William H. Wood III, Kevin G. Becker, Ruin Moaddel, Stuart Maudsley , Bronwen Martin? (2013) Long-Term Artificial Sweetener Acesulfame Potassium Treatment Alters Neurometabolic Functions in C57BL/6J Mice, Plos One, 8, e70257

Identification test

Solubility: easily soluble in water. Very slightly soluble in ethanol. Measure it according to the OT-42 method. Potassium test result (2 g of test residue): positive (IT-27). UV absorbance: take 10 mg of the sample to dissolve in 1000 ml of water and the solution had a maximum absorption peak at 227 ± 2 nm (see GT-29). Take 0.2 g of the sample, add 2 ml of the acetic acid test solution (TS-1) and 2 ml of water. Add several drops of 10% sodium hexachlorocyclohexane solution to this solution, after which there should be a yellow precipitate.

Production method

There are many patents on the preparation of acesulfame, here are four methods. Aminosulfonic acid and diketene method Take aminosulfonic acid, triethylamine, diketene and potassium hydroxide as raw material for synthesis. 9.7 g (0.1 mol) of sulfamic acid was added to 16 mL (0.12 mol) of triethylamine and stirred until complete dissolution. 8 mL 0.104 mol of diketene was added drop wise at 0 ° C, and the mixture was stirred at room temperature until completion of the reaction. Add hexane for precipitation and further refinement and the solvent was removed under reduced pressure to obtain 27 to 28 g of a syrup in a yield of 95.7 to 99.0%. The slurry and SO3 were simultaneously added to the container containing CH2Cl2 for stirring continuously of 1-5 hours before the removal of solvent under reduced pressure. The residue was treated with methanol-potassium hydroxide solution under controlling Ph value of 8 to 10. The solvent was removed and dried to give acesulfame potassium salt in 69% yield. This method is easy to obtain raw materials with mild conditions but the process is complex and the yield is not high. Aminosulfonyl fluoride and diketene method. To a solution of 76 g (0.55 mol) of potassium carbonate powder and 500 mL of acetone, 57.8 mL (1.0 mol) of sulfamic acid fluoride was added, and 84.3 mL (1.1 mol) of diketene was added dropwise over 15 min. Stir for reaction at 0 °C for 30 min. The reaction is exothermic with the temperature be controlled below 30℃ until the CO2 is completely released before stopping the reaction. The reaction mixture was suction filtered and washed with a small amount of acetone to give the potassium salt of the colorless crystalline acetoacetylamino-N-sulfonyl fluoride. The crystal was stirred together with 4 to 6 mol of methanol-potassium hydroxide solution to cyclize to obtain the acesulfame potassium salt in a yield of 93% of the theoretical amount. This method is easier to obtain raw materials with mild process conditions. The operation is also not complicated, being the ideal preparation method. Acetoacetamide and fluorinated sulfuryl fluoride method. Take acetoacetamide, potassium carbonate, fluorinated sulfuryl fluoride and potassium hydroxide as raw materials; (0.1 mol) of acetoacetamide and 69 g (0.5 mol) of potassium carbonate were added to 150 mL of acetone and 8 mL of water. After stirring uniformly, 15.3 g (0.15 mol) of fluorinated sulfuryl fluoride gas was introduced at room temperature for reaction at which point the reaction mixture was allowed to warm to 40 ° C and stirred for 2 h before suction filtration. The filter cake was put into an excess of hydrochloric acid solution of ice to dissolve and react. And then extracted with ethyl acetate. The extract was dried over anhydrous sodium sulfate, and the solvent was removed under reduced pressure to obtain acesulfame. It will react with methanol-potassium hydroxide solution to obtain acesulfame potassium salt with drying to get 14.1 g finished product with the yield of 86.5% of the theoretical amount. This method is not harsh reaction conditions, the yield is high, but some raw materials are not easy to get. Acetoacetamide and sulfur trioxide method. In an inert organic or inorganic solvent, send through SO3 into acetoacetamide for recycling condensation, generating acetoacetyl sulfamic acid. After separation, it is reacted with potassium hydroxide to derive the products. Dissolve 5.1 g (50 mmol) acetoacetamide in 50mLCH2Cl2; dissolve 8 mL (200 mmo1) liquid SO3 in 50 mL Mlch2Cl2; then at-60 ℃, then drop the former one to the latter for stirring reaction of 2h. Add 50 mL acetoacetamide and water and the organic phase was separated after extraction and further subject to aqueous phase extraction with ethyl acetate for twice and combined into the organic phase. After drying over anhydrous sodium sulfate, ethyl acetate was recovered by evaporation. The residue was dissolved in methanol and neutralized with methanol-potassium hydroxide solution. Acesulfame potassium salt was then precipitated and dried, yielding 3.1 g of product in a yield of 31% of the theoretical amount. This method needs to be carried out at low temperature, and the yield is not high. It can be obtained through the addition reaction of fluorosulfonyl isocyanate (or chlorosulfonyl isocyanate) with various active methylene compounds (including α-unsubstituted ketone, β-diketone, β-keto acid and β-ketoester, etc.) addition . For example, from the addition reaction between tert-butyl acetoacetate and fluorosulfonyl isocyanate.

Uses

1. Non-nutritional sweetener, being able to be widely used in various foods, even in drinks of Ph3.0, it can also be used. 2. For beverages, food, health products and so on 3. Food sweeteners 4. Acesulfame belongs to the fourth generation synthetic sweeteners with single administration accompanied with a certain bitter taste. It has a synergistic effect when being used in combination with aspartame or cyclamate and being able to mask the bitter taste. After intake of the human body, it is not absorbed and does not produce heat, being suitable for patients with diabetes and obesity. It can be used as pastry, jam (excluding canned food), pickles, candy, candied fruit, beverage, ice cream and jelly candy with the maximum dosage of 0.3g/kg; it can also be used as table sweetener (flake or powder) with 40 mg per tablet or per packet.

Content analysis

Accurately weighed 0.15g of pre-dried sample, dissolve in 50.0ml glacial acetic acid; apply 0.1mol/L perchloric acid for potentiometric titration; or add two drops of crystal violet test solution (TS-74), titrate with 0.1mol/L perchloric acid titration to blue-green end point, and maintain 30s to perform a blank test at the same time and correct the necessary error. Per mL, 0.1 mol/L perchloric acid is equivalent to 20.12 mg of acesulfame potassium (C4H4NO4SK).

Chemical properties

It appears as colorless to white crystalline powder, being odorless with a strong sweetness which is about 150 times that of the sucrose; the flavor properties are similar as that of saccharin. It has bitter at high concentrations and has a good mixing property with sugar alcohols and sucrose, etc., being stable as well. It has a melting point of about 225 °C, the maximum absorption spectrum of 227nm and density 1.83g/cm3 (loose density 1.1~1.3kg/dm3). It is non-hygroscopic, being stable at room temperature, easily soluble in water (30g/100ml, 20 ℃), slightly soluble in ethanol and other organic solvents.

Description

Acesulfame pottasium (also known as acesulfame K or Ace K) is a calorie free sugar substitute (artificial sweetener). It is ~ 200x sweeter than table sugar and approved for use in food as a non-nutritive sweetener. It is sold under the brand names Sunett? and Sweet One?. FDA approved it as a general purpose sweetener and flavor enhancer in food, except in meat and poultry, under certain conditions of use. It stays sweet even when used at high temperatures during baking, making it suitable as a sugar substitute in baked goods. Acesulfame potassium has been approved for use in a variety of food products including frozen desserts, candies, beverages, baby food, and baked goods. More than 90 studies support its safety. Acesulfame K contains the carcinogen methylene chloride. Long-term exposure to methylene chloride can cause headaches, depression, nausea, mental confusion, liver effects, kidney effects, visual disturbances, and cancer in humans.

Uses

Acesulfame-K is a non-nutritive sweetener also termed acesulfame potassium. it is a white, crystalline product that is 200 times sweeter than sucrose. it is not metabolized in the body. it has some metallic off-tastes. it is readily soluble and heat and acid stable. it provides a synergistic sweetening effect combined with other sweeteners. it is used in beverages, desserts, confectionery, and bakery products.

Usage limit

GB 2760-2001 (g/kg): beverages, ice cream, pastries, confectionery, jam (excluding canned), pickles, candied fruit, jelly candy, canned rice porridge, jelly, bread, 0.3; dining table-purpose sauce(flake like and powder like): 40 mg per tablet and package; Flavorless yogurt, 0.35; flavoring, 0.5; sugarless (low sugar) candy and gum, 2.0; sugarless chewing gum, 4. Limited to GMP (FDA, § 172.800, 2000).
InChI:InChI=1/C4H5NO4S.K/c1-3-2-4(6)5-10(7,8)9-3;/h2H,1H3,(H,5,6,7,8);/q;+1/p-1

33665-90-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name acesulfame

1.2 Other means of identification

Product number -
Other names Acesulfame

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:33665-90-6 SDS

33665-90-6Synthetic route

6-methyl-2,3-dihydro-1,3-oxazin-2,4-dione-3-sulfo-fluoride

6-methyl-2,3-dihydro-1,3-oxazin-2,4-dione-3-sulfo-fluoride

acetosulfam
33665-90-6

acetosulfam

Conditions
ConditionsYield
With sodium hydrogencarbonate In water; acetone86%
With triethylamine In water; ethyl acetate81%
With sodium hydroxide81%
With potassium hydroxide In dichloromethane; water
Triethylammoniumsalz der Acetoacetamid-N-sulfonsaeure
99911-48-5

Triethylammoniumsalz der Acetoacetamid-N-sulfonsaeure

acetosulfam
33665-90-6

acetosulfam

Conditions
ConditionsYield
Stage #1: Triethylammoniumsalz der Acetoacetamid-N-sulfonsaeure With disulfuric acid In dichloromethane at -30 - 4℃; for 0.00116667 - 0.00569444h;
Stage #2: With water In dichloromethane at 0 - 35℃; Product distribution / selectivity;
37 - 91 %Chromat.
Stage #1: Triethylammoniumsalz der Acetoacetamid-N-sulfonsaeure With sulfur trioxide In dichloromethane at -30 - -10℃;
Stage #2: With sulfuric acid; water In dichloromethane at 15 - 25℃; Product distribution / selectivity;
70 %Chromat.
Stage #1: Triethylammoniumsalz der Acetoacetamid-N-sulfonsaeure With sulfur trioxide In dichloromethane at -35 - -25℃;
Stage #2: With water at -22 - -5℃; for 0.166667h;
Stage #1: Triethylammoniumsalz der Acetoacetamid-N-sulfonsaeure With sulfur trioxide In dichloromethane for 1.38889E-05h; Flow reactor;
Stage #2: With water Time;
85 %Chromat.
Stage #1: Triethylammoniumsalz der Acetoacetamid-N-sulfonsaeure With sulfur trioxide In dichloromethane
Stage #2: With water
acetoacetamido
5977-14-0

acetoacetamido

fluorosulfonylchloride
13637-84-8

fluorosulfonylchloride

acetosulfam
33665-90-6

acetosulfam

Conditions
ConditionsYield
With sodium hydroxide; triethylamine In sulfur dioxide
potassium acesulfame
55589-62-3

potassium acesulfame

acetosulfam
33665-90-6

acetosulfam

Conditions
ConditionsYield
With hydrogenchloride In water pH=2;
With hydrogenchloride In water
With hydrogenchloride In water
With hydrogenchloride In water
With hydrogenchloride In water
acetosulfam
33665-90-6

acetosulfam

potassium acesulfame
55589-62-3

potassium acesulfame

Conditions
ConditionsYield
With potassium hydroxide In methanol pH=6.8; pH-value;97%
With potassium hydroxide In methanol; water at 35℃; Product distribution / selectivity;
copper (II) carbonate hydroxide

copper (II) carbonate hydroxide

water
7732-18-5

water

acetosulfam
33665-90-6

acetosulfam

tetraaqua-bis(6-methyl-1,2,3-oxathiazin-4(3H)-onato-2,2-dioxide)copper(II)

tetraaqua-bis(6-methyl-1,2,3-oxathiazin-4(3H)-onato-2,2-dioxide)copper(II)

Conditions
ConditionsYield
at 75℃; for 0.5h;95%
triphenylbismuthane
603-33-8

triphenylbismuthane

acetosulfam
33665-90-6

acetosulfam

C14H13BiN2O8S2
1422436-51-8

C14H13BiN2O8S2

Conditions
ConditionsYield
In diethyl ether at 20℃; for 4h; Temperature; Time;91.8%
acetosulfam
33665-90-6

acetosulfam

4-Chloro-6-methyl-[1,2,3]oxathiazine 2,2-dioxide
72827-09-9

4-Chloro-6-methyl-[1,2,3]oxathiazine 2,2-dioxide

Conditions
ConditionsYield
With phosphorus pentachloride In tetrachloromethane Heating;90%
triphenylbismuthane
603-33-8

triphenylbismuthane

acetosulfam
33665-90-6

acetosulfam

A

Bi(3+)*3C4H4NO4S(1-)

Bi(3+)*3C4H4NO4S(1-)

B

benzene
71-43-2

benzene

Conditions
ConditionsYield
In neat (no solvent) at 90℃; for 1h;A 86%
B n/a
Flucytosine
2022-85-7

Flucytosine

acetosulfam
33665-90-6

acetosulfam

2C4H4FN3O*C4H5NO4S

2C4H4FN3O*C4H5NO4S

Conditions
ConditionsYield
at 20℃;
acetosulfam
33665-90-6

acetosulfam

ammonium 6-methyl-1,2,3-oxathiazin-4(3H)-one-2,2-dioxide

ammonium 6-methyl-1,2,3-oxathiazin-4(3H)-one-2,2-dioxide

Conditions
ConditionsYield
With ammonium carbonate In water at 75℃; for 0.5h;Ca. 0.25 g
theophylline
58-55-9

theophylline

acetosulfam
33665-90-6

acetosulfam

THPAH12

THPAH12

Conditions
ConditionsYield
In neat (no solvent, solid phase)
salicylaldehyde isonicotinoylhydrazone
495-84-1

salicylaldehyde isonicotinoylhydrazone

acetosulfam
33665-90-6

acetosulfam

C13H11N3O2*C4H5NO4S

C13H11N3O2*C4H5NO4S

Conditions
ConditionsYield
In methanol at 20 - 60℃;
cadmium(II) carbonate
739319-89-2

cadmium(II) carbonate

water
7732-18-5

water

acetosulfam
33665-90-6

acetosulfam

Cd(acesulfamate)2(H2O)2

Cd(acesulfamate)2(H2O)2

Conditions
ConditionsYield
at 75℃; for 0.5h;Ca.0.4 g
2CO3(2-)*2Pb(2+)*H2O*PbO

2CO3(2-)*2Pb(2+)*H2O*PbO

acetosulfam
33665-90-6

acetosulfam

lead(II) acesulfamate

lead(II) acesulfamate

Conditions
ConditionsYield
In water at 75℃; for 0.5h;Ca.0.8 g
acetosulfam
33665-90-6

acetosulfam

Quinine
130-95-0

Quinine

C4H5NO4S*C20H24N2O2

C4H5NO4S*C20H24N2O2

Conditions
ConditionsYield
In ethyl acetate for 336h; Solvent;
acetosulfam
33665-90-6

acetosulfam

Quinine
130-95-0

Quinine

2C4H5NO4S*C20H24N2O2

2C4H5NO4S*C20H24N2O2

Conditions
ConditionsYield
In ethanol Solvent;
acetosulfam
33665-90-6

acetosulfam

A

5-chloroacesulfame potassium

5-chloroacesulfame potassium

B

potassium acesulfame
55589-62-3

potassium acesulfame

Conditions
ConditionsYield
With potassium hydroxide at 25℃; for 0.333333h;
C28H62N2(2+)*2HO(1-)

C28H62N2(2+)*2HO(1-)

acetosulfam
33665-90-6

acetosulfam

C28H62N2(2+)*2C4H4NO4S(1-)

C28H62N2(2+)*2C4H4NO4S(1-)

Conditions
ConditionsYield
In methanol
C30H66N2(2+)*2HO(1-)

C30H66N2(2+)*2HO(1-)

acetosulfam
33665-90-6

acetosulfam

C30H66N2(2+)*2C4H4NO4S(1-)

C30H66N2(2+)*2C4H4NO4S(1-)

Conditions
ConditionsYield
In methanol
C32H70N2(2+)*2HO(1-)

C32H70N2(2+)*2HO(1-)

acetosulfam
33665-90-6

acetosulfam

C32H70N2(2+)*2C4H4NO4S(1-)

C32H70N2(2+)*2C4H4NO4S(1-)

Conditions
ConditionsYield
In methanol
C34H74N2(2+)*2HO(1-)

C34H74N2(2+)*2HO(1-)

acetosulfam
33665-90-6

acetosulfam

C34H74N2(2+)*2C4H4NO4S(1-)

C34H74N2(2+)*2C4H4NO4S(1-)

Conditions
ConditionsYield
In methanol
C36H78N2(2+)*2HO(1-)

C36H78N2(2+)*2HO(1-)

acetosulfam
33665-90-6

acetosulfam

C36H78N2(2+)*2C4H4NO4S(1-)

C36H78N2(2+)*2C4H4NO4S(1-)

Conditions
ConditionsYield
In methanol

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