33667-02-6Relevant academic research and scientific papers
METHOD FOR PREPARING CHLORINATED KETONE COMPOUNDS
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Paragraph 0050-0053, (2021/02/04)
PROBLEM TO BE SOLVED: To provide a method for efficiently producing a α-methylene ketone compound, which is widely found in natural products and is known as a biologically active substance, by a method in which an α, α-disubstituted allyl alcohol compound is used as a raw material, and an expensive oxidizing agent such as a heavy metal system is not used and an environmental load is reduced. SOLUTION: An α, α-disubstituted allyl alcohol compound represented by general formula (1) (wherein R1 and R2 each represents an alkyl group, an aromatic hydrocarbon group, or an alicyclic hydrocarbon group; alternatively, R1 and R2 may form together an aliphatic hydrocarbon ring), is oxidized in the presence of tetraalkylammonium hypochlorite to give a chlorinated ketone compound. This chlorinated ketone compound can be made into an α-methylene ketone compound by dehydrochlorination in the presence of a base. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT
