33667-52-6

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 1-benzhydrylazetidine-2-carboxylate is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potentially beneficial properties. Its unique molecular structure allows for the creation of compounds that can target specific biological pathways or receptors, leading to improved therapeutic outcomes.
Used in Organic Compounds Synthesis:
In the field of organic chemistry, methyl 1-benzhydrylazetidine-2-carboxylate is utilized as a building block for the synthesis of a wide range of organic compounds. Its versatility in chemical reactions enables the creation of diverse molecules with various applications, such as agrochemicals, dyes, and other specialty chemicals.
Used in Medicinal Chemistry Research:
Methyl 1-benzhydrylazetidine-2-carboxylate is employed as a valuable component in medicinal chemistry research, where its unique properties are harnessed to explore new drug candidates and optimize their pharmacological profiles. Its potential use in drug development has led to extensive studies aimed at understanding its interactions with biological targets and its role in modulating various biological pathways.

InChI:InChI=1/C18H19NO2/c1-21-18(20)16-12-13-19(16)17(14-8-4-2-5-9-14)15-10-6-3-7-11-15/h2-11,16-17H,12-13H2,1H3

Upstream product

• 29547-04-4 methyl 2,4-dibromobutanoate 
• 91-00-9 Benzhydrylamine 

Downstream Products

• 130054-77-2 Cyano-acetic acid 1-benzhydryl-azetidin-2-ylmethyl ester 
• 72351-68-9 1-diphenylmethyl-2-hydroxymethylazetidine 

Relevant academic research and scientific papers

Preparation comprising an enzyme for asymmetrical hydrolysis of N-substituted C3-C4 cyclic imino-2-carboxylic acid ester and method of using the same

There is disclosed an enzyme preparation comprising: (i) a styrene-divinylbenzene copolymer having fine pores with an average radius of 200 - 500?, and (ii) an enzyme capable of asymmetrically hydrolyzing N-substituted C3-C4 cyclic imino-2-carboxylic acid ester to preferentially produce an (S)-N-substituted C3-C4 cyclic imino-2-carboxylic acid, wherein said enzyme comprises an amino acid sequence as set forth in SEQ ID NO: 1 or the like.

Enzymatic resolution of methyl N-alkyl-azetidine-2-carboxylates by Candida antarctica lipase-mediated ammoniolysis

A facile method for the synthesis of optically active azetidine-2- carboxylic acid derivatives is presented Racemic N-alkylated azetidine esters are resolved by lipase from Candida antarctica in an ammoniolysis reaction, and both the S-amide and the R-ester are obtained with excellent stereoselectivity.

Novel 2-amino-1,4-dihydropyridine calcium antagonists. II. Synthesis and antihypertensive effects of 2-amino-1,4-dihydropyridine derivatives having N,N-dialkylaminoalkoxycarbonyl groups at 3- and/or 5-positions

Novel 2-amino-1,4-dihydropyridine derivatives I, which contain N,N-dialkylaminoalkoxycarbonyl groups at the 3- and/or 5-position, were synthesized and their antihypertensive effects were evaluated in spontaneously hypertensive rats. Remarkably prolonged duration of antihypertensive action was observed when a tertiary amino group was introduced into either the 3- or 5-ester side-chain of the 1,4-dihydropyridine ring. In particular, the compounds containing cyclic amino moieties at the 3-position showed greater potency than those with acyclic amino moieties. Chemical modification studies indicated that the two ester side-chains of 1,4-dihydropyridine at the 3- and 5-position might function in a different manner in relation to the antihypertensive activities. 3-(1-Benzhydrylazetidin-3-yl) 5-isopropyl 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxyl ate, I-43 (CS-905), exhibited potent and long-lasting antihypertensive effects with gradual onset of action, and is a promising candidate as an antihypertensive drug.