3367-95-1

Usage

Uses

1. Used in Pharmaceutical Industry:
N,N-Diethylnipecotamide is used as a reactant for the synthesis of various pharmaceutical compounds, including:
a. Antituberculosis drugs: It serves as a key intermediate in the development of drugs targeting tuberculosis, a bacterial infection that primarily affects the lungs.
b. Spiroimidazolidinone NPC1L1 inhibitors: These inhibitors are used to treat certain medical conditions by targeting the NPC1L1 protein, which plays a role in cholesterol transport.
d. Alpha 7 nicotinic acetylcholine receptor agonists: These agonists have potential applications in the treatment of various neurological and cognitive disorders, such as Alzheimer's disease and schizophrenia.
e. Antimycobacterials: N,N-Diethylnipecotamide is used in the synthesis of antimycobacterial drugs, which are essential in combating mycobacterial infections, including tuberculosis.
f. Isocyanoamides useful as starting materials in IMCR: Isocyanoamides are versatile synthetic intermediates that can be used in the development of various pharmaceutical compounds, including those with potential applications in the treatment of cancer.

InChI:InChI=1/C10H20N2O/c1-3-12(4-2)10(13)9-6-5-7-11-8-9/h9,11H,3-8H2,1-2H3/p+1/t9-/m1/s1

Upstream product

• 59-26-7 N,N-diethylnicotinamide 

Downstream Products

• 4606-65-9 3-(hydroxymethy)piperidine 
• 120990-84-3 3-<(N,N-diethylamino)methyl>piperidine 
• 290354-18-6 C₂₈H₄₅IN₄O₂ 
• 290354-09-5 C₂₈H₄₅N₅O₄ 
• 290354-06-2 C₃₀H₅₀N₄O₃ 
• 1146300-61-9 7-(3-(diethylcarbamoyl)piperidin-1-yl)-1-(2,4-difluorophenyl)-1,4-dihydro-8-methyl-6-nitro-4-oxoquinoline-3-carboxylic acid 
• 1119087-64-7 7-(3-(diethylcarbamoyl)piperidin-1-yl)-1,4-dihydro-1-(4-fluorophenyl)-6-nitro-4-oxoquinoline-3-carboxylic acid 
• 1187181-98-1 1-[4-(4-bromophenylcarbamoyl)butyl]piperidine-3-carboxylic acid diethylamide 
• 1188338-95-5 5-(2-benzamidoethyl)-4-{N-3-[(N,N-diethylcarboxamido)piperidin-1-yl]carbonyl}-1-phenyl-1H-pyrazole 

Relevant academic research and scientific papers

Cobalt-bridged secondary building units in a titanium metal-organic framework catalyze cascade reduction of N-heteroarenes

We report here a novel Ti3-BPDC metal-organic framework (MOF) constructed from biphenyl-4,4′-dicarboxylate (BPDC) linkers and Ti3(OH)2 secondary building units (SBUs) with permanent porosity and large 1D channels. Ti-OH groups from neighboring SBUs point toward each other with an O-O distance of 2 ?, and upon deprotonation, act as the first bidentate SBU-based ligands to support CoII-hydride species for effective cascade reduction of N-heteroarenes (such as pyridines and quinolines) via sequential dearomative hydroboration and hydrogenation, affording piperidine and 1,2,3,4-tetrahydroquinoline derivatives with excellent activity (turnover number ～ 1980) and chemoselectivity.

Facile Reduction of Pyridines with Nickel-Aluminum Alloy

Nickel-aluminum alloy in dilute base can be used to reduce a variety of pyridines, quinolines, and isoquinoline to the corresponding piperidines, 1,2,3,4-tetrahydroquinolines, and 1,2,3,4-tetrahydroisoquinoline in good yield.The reaction is simple to perform, and high temperatures, high pressures, or hydrogen atmospheres are not required.The reaction is accelerated by substituents in the 2-position and by electron-withdrawing groups in the 3- and 4-positions while electron-supplying groups in the 3- and 4-positions retard the reaction.The major product isolated from the reduction of 2-phenylpyridine was 2-cyclohexylpiperidine hydrochloride.With isoniazid (1) and iproniazid (4) the pyridine ring is hydrogenated before the hydrazine is cleaved.