3367-95-1

Basic information

• Product Name: N,N-DIETHYLNIPECOTAMIDE
• Synonyms: 3-(N,N-Diethylcarbamoyl)piperidine;3-Piperidinecarboxamide, N,N-diethyl-;n,n-diethyl-3-piperidinecarboxamid;N,N-Diethyl-3-piperidinecarboxamide;n,n-diethyl-nipecotamid;N,N-Diethylnipeotamide;LABOTEST-BB LT00159306;N,N-DIETHYLNIPECOTAMIDE
• CAS NO: 3367-95-1
• Molecular Formula: C₁₀H₂₀N₂O
• Molecular Weight: 184.28
• EINECS: 222-136-1
• Product Categories: API intermediates;Building Blocks;Heterocyclic Building Blocks;Piperidines;Building Blocks;C10;Chemical Synthesis;Heterocyclic Building Blocks
• Mol File: 3367-95-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 111 °C6.1 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 0.989 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.000648mmHg at 25°C
• Refractive Index: n20/D 1.489(lit.)
• CAS DataBase Reference: N,N-DIETHYLNIPECOTAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-DIETHYLNIPECOTAMIDE(3367-95-1)
• EPA Substance Registry System: N,N-DIETHYLNIPECOTAMIDE(3367-95-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: QU1920000
• Hazardous Substances Data: 3367-95-1(Hazardous Substances Data)

Usage

Chemical Properties

CLEAR COLOURLESS TO YELLOW LIQUID

Uses

N,N-Diethylnipecotamide is a reactant for synthesis of: Antituberculosis drugs1 Spiroimidazolidinone NPC1L1 inhibitors2 Acyl-CoA:cholesterol acyltransferase inhibitors3 Alpha 7 nicotinic acetylcholine receptor agonist4 Antimycobacterials5 Isocyanoamides useful as starting materials in IMCR6

InChI:InChI=1/C10H20N2O/c1-3-12(4-2)10(13)9-6-5-7-11-8-9/h9,11H,3-8H2,1-2H3/p+1/t9-/m1/s1

Upstream product

• 59-26-7 N,N-diethylnicotinamide 

Downstream Products

• 4606-65-9 3-(hydroxymethy)piperidine 
• 120990-84-3 3-<(N,N-diethylamino)methyl>piperidine 
• 1187181-98-1 1-[4-(4-bromophenylcarbamoyl)butyl]piperidine-3-carboxylic acid diethylamide 
• 1188338-95-5 5-(2-benzamidoethyl)-4-{N-3-[(N,N-diethylcarboxamido)piperidin-1-yl]carbonyl}-1-phenyl-1H-pyrazole 
• 1119087-64-7 7-(3-(diethylcarbamoyl)piperidin-1-yl)-1,4-dihydro-1-(4-fluorophenyl)-6-nitro-4-oxoquinoline-3-carboxylic acid 
• 1146300-61-9 7-(3-(diethylcarbamoyl)piperidin-1-yl)-1-(2,4-difluorophenyl)-1,4-dihydro-8-methyl-6-nitro-4-oxoquinoline-3-carboxylic acid 
• 940871-19-2 1-(4-(2-(3-(5-t-butyl-2-p-tolyl-2H-pyrazol-3-yl)-ureidomethyl)phenoxy)pyrimidin-2-yl)piperidin-3-carboxylic acid diethylamide 

Relevant articles and documents

Cobalt-bridged secondary building units in a titanium metal-organic framework catalyze cascade reduction of N-heteroarenes

We report here a novel Ti3-BPDC metal-organic framework (MOF) constructed from biphenyl-4,4′-dicarboxylate (BPDC) linkers and Ti3(OH)2 secondary building units (SBUs) with permanent porosity and large 1D channels. Ti-OH groups from neighboring SBUs point toward each other with an O-O distance of 2 ?, and upon deprotonation, act as the first bidentate SBU-based ligands to support CoII-hydride species for effective cascade reduction of N-heteroarenes (such as pyridines and quinolines) via sequential dearomative hydroboration and hydrogenation, affording piperidine and 1,2,3,4-tetrahydroquinoline derivatives with excellent activity (turnover number ～ 1980) and chemoselectivity.