336784-92-0Relevant articles and documents
Pharmaceutical compositions useful in prevention and treatment of beta-Amyloid protein-induced disease
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Page/Page column 23; sheet 7, (2008/06/13)
The invention provides methods for treating beta-Amyloid protein-induced disease, pharmaceutical compositions and compounds useful for the same, and the use of these compounds for the manufacture of a medicament for treating the same. More particularly, the invention relates to the use of natural product compounds isolated from turmeric, gingko biloba, and ginger, and synthetic chemical analogues thereof, for the treatment of a beta-Amyloid protein-induced disease.
Side-chain length is important for shogaols in protecting neuronal cells from β-amyloid insult
Kim, Darrick S. H. L.,Kim, Jin Yung
, p. 1287 - 1289 (2007/10/03)
Ten shogaols were synthesized to evaluate the importance of the side-chain length in protecting cells from βA(1-42) insult using PC12 rat pheochromocytoma and IMR-32 human neuroblastoma cells. The compounds cell protectivity against βA insult was demonstrated using 3-[4,5- dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) reduction assay. The efficacy of cell protection from βA insult by these shogaols was shown to improve as the length of the side chain increase.