33682-88-1Relevant academic research and scientific papers
Catalytic intermolecular aldol reactions of transient amide enolates in domino Michael/aldol reactions of nitroalkanes, acrylamides, and aldehydes
Morita, Shunya,Yoshimura, Tomoyuki,Matsuo, Jun-Ichi
supporting information, p. 1160 - 1164 (2021/02/26)
Three-component reactions of nitroalkanes, acrylamides, and aldehydes by using a catalytic amount of KOH in DMSO gave β′-hydroxy-γ-nitro amides. Mechanistic studies suggested that the reactions proceeded by domino Michael/aldol reactions. The highly nucle
Direct asymmetric dynamic kinetic resolution by combined lipase catalysis and nitroaldol (Henry) reaction
Vongvilai, Pornrapee,Larsson, Rikard,Ramstroem, Olof
supporting information; experimental part, p. 448 - 452 (2009/04/10)
The asymmetric synthesis of β-nitroalkanol derivatives was simply achieved by a combined nitroaldol (Henry) reaction with lipase-catalyzed transesterification in high yield and enantiomeric purity (up to 92% and 99% ee) through a direct one-pot procedure.
