336879-49-3Relevant academic research and scientific papers
Systematic study of the synthesis of macrocyclic dipeptide β-turn mimics possessing 8-, 9-, and 10- membered rings by ring-closing metathesis
Kaul, Ramesh,Surprenant, Simon,Lubell, William D.
, p. 3838 - 3844 (2007/10/03)
A systematic study was performed to establish general synthesis protocols for forming enantiomerically pure macrocyclic dipeptide lactams. Focusing on macrocycles of 8-, 9-, and 10-membered rings, effective syntheses were achieved by a sequence featuring
Design, synthesis, and conformational analysis of eight-membered cyclic peptidomimetics prepared using ring closing metathesis
Creighton, Christopher J.,Leo, Gregory C.,Du, Yanming,Reitz, Allen B.
, p. 4375 - 4385 (2007/10/03)
As part of a program to identify novel scaffolds that adopt defined secondary structure when incorporated into peptides, we have designed and prepared a library of constrained eight-membered ring lactams based upon 7-amino-8-oxo-1,2,3,6,7-pentahydroazocin
Synthesis of an eight-membered cyclic pseudo-dipeptide using ring closing metathesis
Creighton, Christopher J.,Reitz, Allen B.
, p. 893 - 895 (2007/10/03)
matrix presented Ring closing metathesis of diallylglycine 6 provided cyclic Z-olefin 7 in 80% yield. The reaction was promoted by substitution of the amide nitrogen with the 2,4-dimethoxybenzyl group allowing for the required cis diallylglycine amide rot
