33698-63-4

Upstream product

• 49815-62-5 4-(2',6',6'-trimethyl-2'-cyclohexenyl)-1,6-heptadien-4-ol 

Downstream Products

• 108391-21-5 (1α,2α,4α,5β)-5-Methylbicyclo<2.1.1>hex-2-yl-p-brombenzolsulfonat 
• 108292-69-9 (1α,2β,4α,5β)-5-Methylbicyclo<2.1.1>hex-2-yl-p-brombenzolsulfonat 
• 108292-67-7 C₁₄H₁₈N₂O₂S 
• 108391-19-1 C₁₄H₁₈N₂O₂S 

Relevant academic research and scientific papers

172. β-Cleavage of Bis(homoallylic) Potassium Alkoxides. Two-Step Preparation of Propenyl Ketones from Carboxylic Esters. Synthesis of ar-Turmerone, α-Damascone, β-Damascone, and β-Damascenone

The transformation of 36 bis(homoallylic) alcohols VII to alkenones IX and X via β-cleavage of their potassium alkoxides VIIa in HMPA has been investigated (cf.Scheme 2).These studies have established an order of β-cleavage for 2-propenyl, 1-methyl-2-propenyl, 2-methyl-2-propenyl, 1,1-dimethyl-2-propenyl, and benzyl groups in alkoxides 49a-56a and have allowed a comparison between the β-cleavage reaction and the oxy-Cope rearrangement in alkoxides 74a-83a.As illustrative synthetic applications, a two-step preparation of propenyl ketones 15-42 from carboxylic esters is described, together with syntheses of ar-turmerone (48), α-damascone ((E)-71), β-damascone ((E)-109), and β-damascenone ((E)-111).