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NORMORPHINE HYDROCHLORIDE METHANOL*SOLUT ION 100 MIC is a pharmaceutical solution containing Normorphine Hydrochloride, a potent opioid analgesic, and Methanol, a solvent. This solution is used for the management of moderate to severe pain and is available in a concentration of 100 micrograms per milliliter (MIC). Normorphine is a metabolite of Morphine and exhibits similar pain-relieving properties, but with a faster onset and shorter duration of action. Methanol, a colorless, volatile, and flammable liquid, serves as a solvent to dissolve the Normorphine Hydrochloride and facilitate its administration. It is essential to handle this solution with care due to the potential risks associated with Methanol exposure, such as toxicity and adverse health effects.

3372-02-9

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3372-02-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 3372-02-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,3,7 and 2 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 3372-02:
(6*3)+(5*3)+(4*7)+(3*2)+(2*0)+(1*2)=69
69 % 10 = 9
So 3372-02-9 is a valid CAS Registry Number.
InChI:InChI=1/C16H17NO3/c18-11-3-1-8-7-10-9-2-4-12(19)15-16(9,5-6-17-10)13(8)14(11)20-15/h1-4,9-10,12,15,17-19H,5-7H2/t9?,10-,12+,15+,16+/m1/s1

3372-02-9Downstream Products

3372-02-9Relevant academic research and scientific papers

Efficient iron-catalyzed n-demethylation of tertiary amine-N-oxides under oxidative conditions

Kok, Gaik B.,Scammells, Peter J.

, p. 1515 - 1521 (2012/02/04)

An investigation into the influence of oxidative conditions on the efficiency of opiate N-demethylation using iron powder has been carried out under non-classical Polonovski conditions. This approach involves a two-step process of N-oxidation and subsequent treatment of the intermediate N-oxide hydrochloride with the redox catalyst. Significant improvements in rate and yield have been realized for these reactions in the presence of molecular oxygen. In this context, further rate enhancement was achieved by the judicious addition of small amounts of ferric ions, leading to a concomitant reduction in the amount of the zero-valent iron primary catalyst that is required. This has led to a generalized improved methodology for the N-demethylation of oripavine, codeine, morphine, and thebaine. This protocol can also be carried out in one-pot without the need to isolate the intermediate N-oxide.

Two-step iron(0)-mediated N-demethylation of N -methyl alkaloids

Kok, Gaik B.,Pye, Cory C.,Singer, Robert D.,Scammells, Peter J.

experimental part, p. 4806 - 4811 (2010/10/19)

(Figure Presented) A mild and simple two-step Fe(0)-mediated N-demethylation of a number of tertiary N-methyl alkaloids is described. The tertiary N-methylamine is first oxidized to the corresponding N-oxide, which is isolated as the hydrochloride salt. Subsequent treatment of the N-oxide hydrochloride with iron powder readily provides the N-demethylated amine. Representative substrates include a number of opiate and tropane alkaloids. Key intermediates in the synthesis of semisynthetic 14-hydroxy pharmaceutical opiates such as oxycodone and oxymorphone are also readily N-demethylated using this method.