33720-94-4

Usage

Type of compound

Synthetic chemical compound

Primary uses

a. Anti-helminthic (treats parasitic worm infections)
b. Immunomodulator (potential use in autoimmune diseases and cancer treatment)

Mechanism of action

Interferes with the metabolism of the worm, leading to paralysis and expulsion from the body

Side effects

Associated with serious side effects

Legal status

Banned in some countries due to potential for abuse as a recreational drug

Upstream product

• 675-20-7 piperidin-2-one 
• 5394-63-8 2,2,6-trimethyl-4H-1,3-dioxin-4-one 

Downstream Products

• 126686-07-5 4-acetyl-4,10a-epoxy-2,3,3a,4,7,8,9,10,10a,10b-decahydro-1,3,5-trioxo-2-phenyl-1H-pyrrolo<3,4-a>-4H-quinolizine 
• 126686-07-5 4-acetyl-4,10a-epoxy-2,3,3a,4,7,8,9,10,10a,10b-decahydro-1,3,5-trioxo-2-phenyl-1H-pyrrolo<3,4-a>-4H-quinolizine 
• 126686-07-5 C₁₉H₁₈N₂O₅ 

Relevant academic research and scientific papers

Catalytic asymmetric [3+2] cycloaddition of isomünchnones with methyleneindolinones

An efficient enantioselective [3+2] cycloaddition of isomünchnones with methyleneindolinones that are generated by anin situintramolecular addition of the carbonyl group to rhodium carbenes is realized with a chiralN,N′-dioxide/Zn(ii) complex as a Lewis acid. A series of chiral oxa-bridged 3-spiropiperidines are obtained in high yields with excellent dr and excellent ee values.

Synthesis of Nitrogen-Containing Polycycles via Rhodium(II)-Induced Cyclization-Cycloaddition and Insertion Reactions of N-(Diazoacetoacetyl)amides. Conformational Control of Reaction Selectivity

A series of diazoacetoacetamides, when treated with a catalytic quantity of a rhodium(II) carboxylate, were found to afford products derived from both a carbonyl ylide intermediate and intramolecular C-H insertion.With 3-(N-(diazoacetoacetyl)amino)propano

SYNTHESIS OF AZA SUBSTITUTED POLYCYCLES VIA RHODIUM (II) CARBOXYLATE INDUCED CYCLIZATION OF DIAZOIMIDES

Treatment of several substituted diazoimide derivatives with rhodium (II) carboxylates results in nitrogen-containing cyclic carbonyl ylide formation followed by 1,3-dipolar cycloaddition.

Synthesis of N-Acylacetoacetamide using 2,2,6-Trimethyl-1,3-dioxin-4-one

Diketene-acetone adduct (2,2,6-trimethyl-1,3-dioxin-4-one) 1 reacts with amide NH to give the corresponding N-acetoacetates 2.Formamide and basic amides such as picolinamide, on treatment with the adduct, are transformed to the N-acyl-2,6-dimethyl-4-oxo-4H-pyran-3-carboxamide (4a and 4p) together with the corresponding N-acetoacetates.Keywords--diketene-acetone adduct; 1,3-dioxin-4-one; acetylketene; diketene; acetoacetylation; 4-pyrone derivatives; N-acylacetoacetamide