337307-12-7

Basic information

• Product Name: ((2S,4R)-2-Azidomethyl-4-tritylsulfanyl-pyrrolidin-1-yl)-[2-(2,4-difluoro-benzoyl)-phenyl]-methanone
• CAS NO: 337307-12-7
• Molecular Weight: 644.745
• Mol File: 337307-12-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ((2S,4R)-2-Azidomethyl-4-tritylsulfanyl-pyrrolidin-1-yl)-[2-(2,4-difluoro-benzoyl)-phenyl]-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: ((2S,4R)-2-Azidomethyl-4-tritylsulfanyl-pyrrolidin-1-yl)-[2-(2,4-difluoro-benzoyl)-phenyl]-methanone(337307-12-7)
• EPA Substance Registry System: ((2S,4R)-2-Azidomethyl-4-tritylsulfanyl-pyrrolidin-1-yl)-[2-(2,4-difluoro-benzoyl)-phenyl]-methanone(337307-12-7)

Safety Data

• Hazardous Substances Data: 337307-12-7(Hazardous Substances Data)

Upstream product

• 393791-87-2 (2S,4R)-2-methanesulfonyloxymethyl-4-tritylsulfanylpyrrolidine-1-carboxylic acid tert-butyl ester 
• 176306-17-5 (2S,4R)-4-tritylsulfanylpyrrolidine-1,2-dicarboxylic acid 1-tert-butyl-2-methyl diester 
• 337307-11-6 (2S,4R)-2-azidomethyl-4-tritylsulfanylpyrrolidine-1-carboxylic acid tert-butyl ester 
• 337307-10-5 (2S,4R)-2-Hydroxymethyl-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 121147-93-1 (2S,4S)-2-methyl N-Boc-4-((methylsulfonyl)oxy)pyrrolidine-2-carboxylate 
• 74844-91-0 (2S,4S)-N-tert-butoxycarbonyl-4-hydroxyproline methyl ester 
• 372-18-9 1,3-Difluorobenzene 
• 85-44-9 phthalic anhydride 
• 135030-72-7 2-(2,4-difluorobenzoyl)benzoic acid 
• 393792-04-6 (2S,4R)-2-azidomethyl-4-tritylsulfanylpyrrolidine 

Downstream Products

• 341973-06-6 Pyrrophenone 

Relevant articles and documents

Pyrrolidine inhibitors of human cytosolic phospholipase A2. Part 2: Synthesis of potent and crystallized 4-triphenylmethylthio derivative 'pyrrophenone'

We synthesized a potent and crystallized human cytosolic phospholipase A2α inhibitor, pyrrophenone (6) which inhibits the isolated enzyme with an IC50 value of 4.2 nM. Pyrrophenone shows potent inhibition of arachidonic acid release, prostaglandin E2, thromboxane B2, and leukotriene B4 formation in human whole blood. The magnitudes of prostaglandin E2 and thromboxane B2 inhibition are the same as those of indomethacin.