337354-75-3Relevant academic research and scientific papers
Synthesis, antidepressant evaluation and QSAR studies of novel 2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-N-(substituted phenyl)acetamides
Shelke, Suhas M.,Bhosale, Sharad H.
supporting information; experimental part, p. 4661 - 4664 (2010/10/02)
In search for novel antidepressants, a series of 2-(5H-[1,2,4]triazino[5,6- b]indol-3-ylthio)-N-(substituted phenyl)acetamides was synthesized and screened for potential antidepressant activity by tail suspension test (TST) in mice. Number of synthesized compounds exhibited impressive antidepressant activity, measured in terms of percentage decrease in immobility duration (%DID). QSAR analysis was also undertaken which correlated three parameters FOSA, PISA, and glob with biological activity.
