337356-05-5

Upstream product

• 107-13-1 acrylonitrile 

Downstream Products

• 713137-93-0 acetic acid 1-[3-(2-chloro-phenyl)-isoxazol-5-yl]-2-cyano-allyl ester 
• 852287-77-5 3-[3-(2-chloro-phenyl)-isoxazol-5-yl]-2-[(4-fluoro-benzylamino)-methyl]-3-hydroxy-propionitrile 
• 852287-72-0 2-(benzylamino-methyl)-3-[3-(2-chloro-phenyl)-isoxazol-5-yl]-3-hydroxy-propionitrile 
• 852287-96-8 (2-amino-1-benzyl-1,4,5,6-tetrahydro-pyrimidin-5-yl)-[3-(2-chloro-phenyl)-isoxazol-5-yl]-methanol 
• 852287-89-9 2-aminomethyl-1-[3-(2-chloro-phenyl)-isoxazol-5-yl]-3-(4-fluoro-benzylamino)-propan-1-ol 
• 852287-84-4 2-aminomethyl-3-benzylamino-1-[3-(2-chloro-phenyl)-isoxazol-5-yl]-propan-1-ol 

Relevant academic research and scientific papers

Baylis-Hillman reaction assisted parallel synthesis of 3,5-disubstituted isoxazoles and their in vivo bioevaluation as antithrombotic agents

The solution-phase parallel synthesis involving reactions of Baylis-Hillman products of 3-substituted-5-isoxazolecarbaldehydes with nucleophiles and their in vivo antithrombotic evaluations are described along with the results of in vitro platelet aggregation inhibition assay of a few compounds. Results of the detailed evaluation of one of the compounds as an inhibitor of platelet aggregation are also presented.

5-Isoxazolecarboxaldehyde: A novel substrate for fast Baylis-Hillman reaction

3-Aryl-5-isoxazolecarboxaldehyde undergoes fast Baylis-Hillman reaction with a variety of activated alkenes to yield the corresponding adducts in excellent yields. Some of the Baylis-Hillman adducts reported herein have been subsequently modified to obtai