33739-54-7Relevant academic research and scientific papers
Antagonism of a zinc metalloprotease using a unique metal-chelating scaffold: Tropolones as inhibitors of P. aeruginosa elastase
Fullagar, Jessica L.,Garner, Amanda L.,Struss, Anjali K.,Day, Joshua A.,Martin, David P.,Yu, Jing,Cai, Xiaoqing,Janda, Kim D.,Cohen, Seth M.
supporting information, p. 3197 - 3199 (2013/05/08)
Tropolone emerged from the screening of a chelator fragment library (CFL) as an inhibitor of the Zn2+-dependent virulence factor, Pseudomonas aeruginosa elastase (LasB). Based on this initial hit, a series of substituted tropolone-based LasB inhibitors was prepared, and a compound displaying potent activity in vitro and in a bacterial swarming assay was identified. Importantly, this inhibitor was found to be specific for LasB over other metalloenzymes, validating the usage of tropolone as a viable scaffold for identifying first-in-class LasB inhibitors.
Anti-mycoplasma agent
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, (2008/06/13)
An anti-mycoplasma agent comprising tropolone, its derivatives, represented by the formula: STR1 (wherein R1 is hydroxy, aliphatic acyloxy, arylacyloxy, arysulfonyloxy, carboxyalkyloxy or its ester, benzoylalkyloxy, alkenyloxy, 1,3-dihydro-3-oxo-1-isobenzofuranyloxy, (2-oxo-5-methyl-1,3-dioxol-4-yl)methyloxy or thiocyanato and R2 is hydrogen, halogen, hydroxy, alkyl or alkoxy) and their salts as an active ingredient, which has potent activity especially against tylosin-resistant mycoplasma both in vitro and in vivo and is effectively used in treating the diseases caused thereby.
