33748-00-4

Usage

Uses

Cefixime Impurity can be used in the impurity reference and standard etc.

Upstream product

• 119608-90-1 7-(phenylacetyl)amino-3-vinyl-4-cephalosporanic acid p-methoxybenzyl ester 
• 104146-10-3 (6R,7R)-3-Chloromethyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 94796-13-1 diphenylmethyl 7β-phenylacetamido-3-vinyl-3-cephem-4-carboxylate 
• 64308-63-0 (6R,7R)-benzhydryl 3-(chloromethyl)-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 

Downstream Products

• 79349-82-9 (6R,7R)-7-amino-3-vinyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 

Relevant academic research and scientific papers

7-phenylacetylamino-3-vinyl-4- spore olefine acid method for the preparation of P-methoxybenzyl ester

The invention discloses a preparation method of 7-phenylacetamido-3-vinyl-4-p-methoxy benzyl ester cefotaximate and belongs to the Chemical medicine field. The preparation method comprises the following steps: carrying out quaternary phosphorization and vinyl reaction at the same time on 7-phenylacetamido-3-chloromethyl-4-p-methoxy benzyl ester cefotaximate (GCLE), sodium iodide, triphenylphosphine and formaldehyde solution in a mixed system of dichloromethane, acetone and water to obtain 7-phenylacetamido-3-vinyl-4-p-methoxy benzyl ester cefotaximate; and removing 7-amino and 4-carboxyl protecting group according to known methods to prepare cefixime and cefdinir nuclear parent 7-AVCA (7-amino-3-vinyl-4-cephalosporanic acid). The aqueous phase comprising sodium iodide and excessive formaldehyde can be repeatedly applied, so that the utilization ratio of sodium iodide is remarkably improved, the production cost is lowered, and the environmental pollution caused by formaldehyde is reduced. The preparation method disclosed by the invention is low in production cost, simple in operating method and suitable for industrialized production and the raw materials are easily available in the preparation process.

A method for synthesizing spore parent nucleus antibiotiki head

The invention belongs to the technical field of synthesis of cephalosporin intermediates and in particular relates to a synthesis method of antibiotic cephalosporin mother nucleus. The synthesis method of the antibiotic cephalosporin mother nucleus comprises the following steps: (1) preparing a reaction liquid I; (2) preparing a reaction liquid II; (3) preparing a compound GVNA; and (4) preparing AVNA. The synthesis method of the antibiotic cephalosporin mother nucleus has the advantages that production cost is low, reaction time is short, recovery rate of the organic solvent is high, secondary utilization is facilitated, and product yield is high.

An improved and scaleable preparation of 7-amino-3-vinylcephem-4-carboxylic acid

A practical and efficient multikilogram-scale preparation of 7-amino-3-vinylcephem-4-carboxylic acid (7-AVCA), a key intermediate used in the synthesis of cefixime and cefdinir, is described utilizing /p-methoxybenzyl 7-phenylacetamido-3-chloromethylcephe