337495-00-8Relevant articles and documents
Preparation of trifluoromethylanilines
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, (2008/06/13)
The invention relates to a process for the preparation of trifluoromethylanilines of formula (I) wherein R1is hydrogen, fluorine, chlorine, bromine, methyl, monochloromethyl, dichloromethyl, or formyl, and R2is hydrogen, fluorine or chlorine, with the proviso that when R1and R2are both hydrogen, the amino group is para to the trifluoromethyl group, comprising (a) nitrating a benzotrichloride of formula (II) ?wherein R1and R2are each as defined for formula (I), thereby forming a nitrobenzotrichloride, (b) converting the trichloromethyl group of the nitrobenzotrichloride into a trifluoromethyl group by reaction with anhydrous hydrofluoric acid, thereby forming a nitrobenzotrifluoride, and (c) reducing the nitro groups of the nitrobenzotrifluoride to form a trifluoromethylaniline of formula (I).