33767-87-2

Usage

Uses

Used in Scientific Research:
(5alpha,17beta)-3-oxoestran-17-yl acetate is used as a research tool for studying the mechanisms of estrogen action in the female reproductive system and secondary sexual characteristics. It aids in comprehending the interactions between estrogen receptors and their target tissues.
Used in Pharmaceutical Industry:
(5alpha,17beta)-3-oxoestran-17-yl acetate is used as a precursor in the synthesis of other estrogenic compounds, which can be utilized for the development of medications targeting hormone-related conditions and therapies.
Used in Hormone Replacement Therapy:
(5alpha,17beta)-3-oxoestran-17-yl acetate may be used as a component in hormone replacement therapy, particularly for conditions where estrogen levels need to be supplemented, such as menopause or specific gynecological disorders.
Used in Fertility Treatments:
(5alpha,17beta)-3-oxoestran-17-yl acetate may also be employed in fertility treatments, where understanding and modulating estrogen levels are crucial for successful conception and pregnancy maintenance.

Upstream product

• 1425-10-1 17β-hydroxyestr-4-en-3-one 17-acetate 
• 434-22-0 19-nortestosterone 
• 1434-85-1 17β-hydroxy-5α-estran-3-one 
• 108-24-7 acetic anhydride 
• 1425-10-1 19-nortestosterone acetate 
• 3801-28-3 17β-acetoxy-6α-fluoro-4-estren-3-one 

Downstream Products

• 15019-21-3 17β-acetoxy-5α-estr-1-en-3-one 

Relevant academic research and scientific papers

Synthesis of C-6 fluoroandrogens: Evaluation of ligands for tumor receptor imaging

Seven androgens, substituted with fluorine at C-6, were prepared as potential imaging agents for androgen receptor-positive prostate tumors and were evaluated in vitro in terms of their lipophilicity and their relative binding affinities (RBA, relative to R1881 = 100) for the androgen receptor and for sex steroid binding protein.Introduction of a fluorine atom into the C-6 position of an androgen generally decreases binding affinity to the androgen receptor, except in the two cases: 6α-fluoro-19-nor-testosterone RBA = 41.6 versus 30.6 for the unsubstituted steroid) and 6α-fluorotestosterone (RBA = 8.9 versus 6.6).Receptor binding of the C-6 fluoro-androgens is also stereospecific, showing higher binding affinities for the α-epimers compared to the corresponding β-epimers (4:1 - 15:1).Binding affinity to sex steroid binding protein is the lowest with 19-nor-testosterone, which is also the least lipophilic androgen studied.Based on the binding properties of compounds in this series, 6α-fluoro-19-nor-testosterone appears to have the most promise as a tumor imaging agent. - Keywords: C-6-fluoroandrogens; fluorine substitution; relative binding affinity; 6α- and 6β-epimers; log Po/w; prostate tumors

Stereochemistry of the Palladium-catalyzed Hydrogenation of 3-Oxo-4-ene Steroids. V. A Kinetic Study in Basic and Acidic Media

Effects of the β-methyl group at C-10 and some oxygen functions (=O, OH, OAc) at C-11, C-17, and C-20 on the rates of hydrogenation of 3-oxo-4-ene steroids have been studied with palladium catalyst in pyridine or THF/HBr as solvent.In contrast to the hydrogenation in pyridine, the rate in THF/HBr was greatly depressed by the presence of 10β-methyl group.The reactivity of the steroids was enhanced by the oxygen functions, in particular, by 11, 17-dioxo group.The effects of the substituents are discussed from a mechanistic consideration based on the obtained results.