33767-88-3Relevant academic research and scientific papers
11β-Nitrate Estrane Analogues: Potent Estrogens
Peters, Richard H.,Crowe, David F.,Avery, Mitchell A.,Chong, Wesley K. M.,Tanabe, Masato
, p. 2306 - 2310 (1989)
Various estrane derivatives 1 reacted with cerium ammonium nitrate (CAN) selectively and efficiently to provide 9α,11β-difunctionalized derivatives 2, which were subsequently deoxygenated at C-9 with triethylsilane/boron trifluoride etherate to the desired target 11β-nitratoestranes 3a, 3b, and 5.When examined for estrogenic and postcoital antifertility activity, 11β-nitrates 2c, 2d, and 3b most notably displayed more potent oral activity than did ethynylestradiol.
Process for the preparation of 11-β-nitro-oxysteroids
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, (2008/06/13)
Process for preparing 9 α-hydroxy-11 β-nitro-oxysteroids having a aromatic ring A wherein an aromatic A-ring-containing 9, 11-unsubstituted steroid or corresponding 9,11-dehydrosteroid is oxidized with ceric ions in the presence of nitrate ions.
